Cargando…

Neural stem cell small extracellular vesicle-based delivery of 14-3-3t reduces apoptosis and neuroinflammation following traumatic spinal cord injury by enhancing autophagy by targeting Beclin-1

Neural stem cell-derived small extracellular vesicles (NSC-sEVs) play an important role in the repair of tissue damage. Our previous in vitro and in vivo studies found that preconditioning with NSC-sEVs promoted the recovery of functional behaviors following spinal cord injury by activating autophag...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rong, Yuluo, Liu, Wei, Lv, Chengtang, Wang, Jiaxing, Luo, Yongjun, Jiang, Dongdong, Li, Linwei, Zhou, Zheng, Zhou, Wei, Li, Qingqing, Yin, Guoyong, Yu, Lipeng, Fan, Jin, Cai, Weihua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782003/ https://www.ncbi.nlm.nih.gov/pubmed/31563124 http://dx.doi.org/10.18632/aging.102283

Ejemplares similares

Neural stem cell-derived small extracellular vesicles attenuate apoptosis and neuroinflammation after traumatic spinal cord injury by activating autophagy
por: Rong, Yuluo, et al.
Publicado: (2019)

MicroRNA-421-3p-abundant small extracellular vesicles derived from M2 bone marrow-derived macrophages attenuate apoptosis and promote motor function recovery via inhibition of mTOR in spinal cord injury
por: Wang, Jiaxing, et al.
Publicado: (2020)

14-3-3τ Regulates Beclin 1 and Is Required for Autophagy
por: Wang, Bing, et al.
Publicado: (2010)

Interactions between the MMP‐3 gene rs591058 polymorphism and occupational risk factors contribute to the increased risk for lumbar disk herniation: A case‐control study
por: Luo, Yongjun, et al.
Publicado: (2020)

Engineered extracellular vesicles for delivery of siRNA promoting targeted repair of traumatic spinal cord injury
por: Rong, Yuluo, et al.
Publicado: (2022)

miR-210-5p promotes epithelial–mesenchymal transition by inhibiting PIK3R5 thereby activating oncogenic autophagy in osteosarcoma cells
por: Liu, Wei, et al.
Publicado: (2020)

Neuron-derived exosomes-transmitted miR-124-3p protect traumatically injured spinal cord by suppressing the activation of neurotoxic microglia and astrocytes
por: Jiang, Dongdong, et al.
Publicado: (2020)

14‐3‐3ζ binds to and stabilizes phospho‐beclin 1(S295) and induces autophagy in hepatocellular carcinoma cells
por: Tang, Yufu, et al.
Publicado: (2019)

Small extracellular vesicles encapsulating CCL2 from activated astrocytes induce microglial activation and neuronal apoptosis after traumatic spinal cord injury
por: Rong, Yuluo, et al.
Publicado: (2021)

Correction to: Small extracellular vesicles encapsulating CCL2 from activated astrocytes induce microglial activation and neuronal apoptosis after traumatic spinal cord injury
por: Rong, Yuluo, et al.
Publicado: (2021)

USP14 regulates autophagy by suppressing K63 ubiquitination of Beclin 1
por: Xu, Daichao, et al.
Publicado: (2016)

Cervical intradural disc herniation with Brown-Séquard syndrome: case report and literature review
por: Rong, Yuluo, et al.
Publicado: (2019)

Establishment of a nomogram for predicting the surgical difficulty of anterior cervical spine surgery
por: Ji, Chengyue, et al.
Publicado: (2021)

Exosomal miRNA-128-3p from mesenchymal stem cells of aged rats regulates osteogenesis and bone fracture healing by targeting Smad5
por: Xu, Tao, et al.
Publicado: (2020)

Role for autophagy-related markers Beclin-1 and LC3 in endometriosis
por: Kong, Zhiwei, et al.
Publicado: (2022)

Expression and significance of autophagy genes LC3, Beclin1 and MMP-2 in endometriosis
por: Sui, Xiaoyu, et al.
Publicado: (2018)

Autophagy-Related Beclin 1 and Head and Neck Cancers
por: Hu, Yang-Jie, et al.
Publicado: (2020)

miR-624-5p promoted tumorigenesis and metastasis by suppressing hippo signaling through targeting PTPRB in osteosarcoma cells
por: Luo, Yongjun, et al.
Publicado: (2019)

Exosome-shuttled miR-216a-5p from hypoxic preconditioned mesenchymal stem cells repair traumatic spinal cord injury by shifting microglial M1/M2 polarization
por: Liu, Wei, et al.
Publicado: (2020)

Autophagy-related protein LC3 and Beclin-1 in the first trimester of pregnancy
por: Chifenti, Barbara, et al.
Publicado: (2013)

Beclin 1 Phosphorylation – at the Center of Autophagy Regulation
por: Menon, Manoj B., et al.
Publicado: (2018)

The Role of Beclin 1-Dependent Autophagy in Cancer
por: Vega-Rubín-de-Celis, Silvia
Publicado: (2019)

Dapper1 promotes autophagy by enhancing the Beclin1-Vps34-Atg14L complex formation
por: Ma, Benyu, et al.
Publicado: (2014)

TRIM3 Negatively Regulates Autophagy Through Promoting Degradation of Beclin1 in Ewing Sarcoma Cells
por: Lu, Qunshan, et al.
Publicado: (2019)

Expression and Clinical Significance of the Autophagy Proteins BECLIN 1 and LC3 in Ovarian Cancer
por: Valente, Guido, et al.
Publicado: (2014)

NEK2 induces autophagy‐mediated bortezomib resistance by stabilizing Beclin‐1 in multiple myeloma
por: Xia, Jiliang, et al.
Publicado: (2020)

Editorial: Beclin 1 and autophagy---in memory of Beth Levine (1960–2020)
por: Xu, Haidong, et al.
Publicado: (2022)

Novel oncogene COPS3 interacts with Beclin1 and Raf-1 to regulate metastasis of osteosarcoma through autophagy
por: Zhang, Fan, et al.
Publicado: (2018)

Siglec-15-induced autophagy promotes invasion and metastasis of human osteosarcoma cells by activating the epithelial–mesenchymal transition and Beclin-1/ATG14 pathway
por: Zheng, Bingxin, et al.
Publicado: (2022)

Bim Inhibits Autophagy by Recruiting Beclin 1 to Microtubules
por: Luo, Shouqing, et al.
Publicado: (2012)

Polyglutamine tracts regulate beclin 1-dependent autophagy
por: Ashkenazi, Avraham, et al.
Publicado: (2017)

DIRAS3-Derived Peptide Inhibits Autophagy in Ovarian Cancer Cells by Binding to Beclin1
por: Sutton, Margie N., et al.
Publicado: (2019)

Induction of autophagy by spermidine is neuroprotective via inhibition of caspase 3-mediated Beclin 1 cleavage
por: Yang, Yi, et al.
Publicado: (2017)

miR-25-3p promotes proliferation and inhibits autophagy of renal cells in polycystic kidney mice by regulating ATG14-Beclin 1
por: Liu, Guojian, et al.
Publicado: (2020)

Expressions and clinical significance of autophagy-related markers Beclin1, LC3, and EGFR in human cervical squamous cell carcinoma
por: Hu, Yun-Feng, et al.
Publicado: (2015)

Effects of an orally supplemented probiotic on the autophagy protein LC3 and Beclin1 in placentas undergoing spontaneous delivery during normal pregnancy
por: Yang, Ping, et al.
Publicado: (2020)

The stress-responsive kinases MAPKAPK2/MAPKAPK3 activate starvation-induced autophagy through Beclin 1 phosphorylation
por: Wei, Yongjie, et al.
Publicado: (2015)

MicroRNA‐30a ameliorates hepatic fibrosis by inhibiting Beclin1‐mediated autophagy
por: Chen, Jianliang, et al.
Publicado: (2017)

CircHIPK3 negatively regulates autophagy by blocking VCP binding to the Beclin 1 complex in bladder cancer
por: Wang, Chong, et al.
Publicado: (2023)

Deregulation of the Expression of Beclin1 and Light Chain 3(LC3), Autophagy-Related Genes, in COVID-19 Patients
por: Boroumand-Noughabi, Samaneh, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_gn24jjeoqulmihlss2ohqbh067