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Vaccine coverage and compliance in Mexico with the two-dose and three-dose rotavirus vaccines

Worldwide, rotavirus infection has been a leading cause of severe diarrhea morbidity and mortality. Two rotavirus vaccines have been used in the National Immunization Program (NIP) in Mexico; two-dose Rotarix from 2006 to 2011 and three-dose RotaTeq since 2011. This study assessed coverage (receivin...

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Autores principales: Luna-Casas, Gerardo, Carreño-Manjarrez, Roberto, Castañeda-Prado, Andrés, Cervantes-Apolinar, Maria Yolanda, Navarro-Rodriguez, Ricardo, Sánchez-González, Gilberto, Cortés-Alcalá, Ricardo, DeAntonio, Rodrigo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783135/
https://www.ncbi.nlm.nih.gov/pubmed/30380975
http://dx.doi.org/10.1080/21645515.2018.1540827
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author Luna-Casas, Gerardo
Carreño-Manjarrez, Roberto
Castañeda-Prado, Andrés
Cervantes-Apolinar, Maria Yolanda
Navarro-Rodriguez, Ricardo
Sánchez-González, Gilberto
Cortés-Alcalá, Ricardo
DeAntonio, Rodrigo
author_facet Luna-Casas, Gerardo
Carreño-Manjarrez, Roberto
Castañeda-Prado, Andrés
Cervantes-Apolinar, Maria Yolanda
Navarro-Rodriguez, Ricardo
Sánchez-González, Gilberto
Cortés-Alcalá, Ricardo
DeAntonio, Rodrigo
author_sort Luna-Casas, Gerardo
collection PubMed
description Worldwide, rotavirus infection has been a leading cause of severe diarrhea morbidity and mortality. Two rotavirus vaccines have been used in the National Immunization Program (NIP) in Mexico; two-dose Rotarix from 2006 to 2011 and three-dose RotaTeq since 2011. This study assessed coverage (receiving at least one dose or full dose series) in eligible infants, compliance (% completing dose series and % completing series on schedule) in eligible infants vaccinated with Rotarix (2010) versus RotaTeq (2012), using Mexican Social Security Institute data nationwide and by regions. In 2010, 80.7% received at least one dose of Rotarix, 75.6% received both doses and 57.0% received both doses on schedule. In 2012, 85.7% received at least one dose of RotaTeq, 61.0% received all three doses and 43.2% received all three doses on schedule. More eligible infants received all doses with Rotarix versus RotaTeq (p < 0.001). Among infants vaccinated with Rotarix versus RotaTeq, 93.7% versus 71.1% completed full series (p < 0.001), and 75.5% versus 70.9% completed full series on schedule (p = 0.105), respectively. The full series coverage and compliance decreased in all regions with RotaTeq compared with Rotarix. In conclusion, rotavirus vaccination has successfully reduced morbidity and mortality in children under 5 years in Mexico. This study found significant differences in full series coverage and compliance among infants and a higher proportion of completed scheduled at an earlier age in Mexico when comparing a two-dose vaccine in 2010 with a three-dose vaccine in 2012. Such differences might need to be taken into consideration to maximize NIP benefits, including early protection of the rotavirus vaccination program.
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spelling pubmed-67831352019-10-18 Vaccine coverage and compliance in Mexico with the two-dose and three-dose rotavirus vaccines Luna-Casas, Gerardo Carreño-Manjarrez, Roberto Castañeda-Prado, Andrés Cervantes-Apolinar, Maria Yolanda Navarro-Rodriguez, Ricardo Sánchez-González, Gilberto Cortés-Alcalá, Ricardo DeAntonio, Rodrigo Hum Vaccin Immunother Research Paper Worldwide, rotavirus infection has been a leading cause of severe diarrhea morbidity and mortality. Two rotavirus vaccines have been used in the National Immunization Program (NIP) in Mexico; two-dose Rotarix from 2006 to 2011 and three-dose RotaTeq since 2011. This study assessed coverage (receiving at least one dose or full dose series) in eligible infants, compliance (% completing dose series and % completing series on schedule) in eligible infants vaccinated with Rotarix (2010) versus RotaTeq (2012), using Mexican Social Security Institute data nationwide and by regions. In 2010, 80.7% received at least one dose of Rotarix, 75.6% received both doses and 57.0% received both doses on schedule. In 2012, 85.7% received at least one dose of RotaTeq, 61.0% received all three doses and 43.2% received all three doses on schedule. More eligible infants received all doses with Rotarix versus RotaTeq (p < 0.001). Among infants vaccinated with Rotarix versus RotaTeq, 93.7% versus 71.1% completed full series (p < 0.001), and 75.5% versus 70.9% completed full series on schedule (p = 0.105), respectively. The full series coverage and compliance decreased in all regions with RotaTeq compared with Rotarix. In conclusion, rotavirus vaccination has successfully reduced morbidity and mortality in children under 5 years in Mexico. This study found significant differences in full series coverage and compliance among infants and a higher proportion of completed scheduled at an earlier age in Mexico when comparing a two-dose vaccine in 2010 with a three-dose vaccine in 2012. Such differences might need to be taken into consideration to maximize NIP benefits, including early protection of the rotavirus vaccination program. Taylor & Francis 2018-12-11 /pmc/articles/PMC6783135/ /pubmed/30380975 http://dx.doi.org/10.1080/21645515.2018.1540827 Text en © 2018 GlaxoSmithKline Biologicals SA. Published with license by Taylor & Francis Group, LLC. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Luna-Casas, Gerardo
Carreño-Manjarrez, Roberto
Castañeda-Prado, Andrés
Cervantes-Apolinar, Maria Yolanda
Navarro-Rodriguez, Ricardo
Sánchez-González, Gilberto
Cortés-Alcalá, Ricardo
DeAntonio, Rodrigo
Vaccine coverage and compliance in Mexico with the two-dose and three-dose rotavirus vaccines
title Vaccine coverage and compliance in Mexico with the two-dose and three-dose rotavirus vaccines
title_full Vaccine coverage and compliance in Mexico with the two-dose and three-dose rotavirus vaccines
title_fullStr Vaccine coverage and compliance in Mexico with the two-dose and three-dose rotavirus vaccines
title_full_unstemmed Vaccine coverage and compliance in Mexico with the two-dose and three-dose rotavirus vaccines
title_short Vaccine coverage and compliance in Mexico with the two-dose and three-dose rotavirus vaccines
title_sort vaccine coverage and compliance in mexico with the two-dose and three-dose rotavirus vaccines
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783135/
https://www.ncbi.nlm.nih.gov/pubmed/30380975
http://dx.doi.org/10.1080/21645515.2018.1540827
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