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Association between the IL-10 rs1800872 polymorphisms and periodontitis susceptibility: A meta-analysis

BACKGROUND: Periodontitis is a common disease with an unclear pathological mechanism. No precise consensus has been reached to evaluate the association between the IL-10 rs1800872 (- 592, -590, -597 C>A) polymorphism and periodontal disease. Thus, we performed this meta-analysis to collect more e...

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Autores principales: Wang, Zao, Li, Yafang, Zhou, Yanheng, Qiao, Yiqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783189/
https://www.ncbi.nlm.nih.gov/pubmed/31577700
http://dx.doi.org/10.1097/MD.0000000000017113
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author Wang, Zao
Li, Yafang
Zhou, Yanheng
Qiao, Yiqiang
author_facet Wang, Zao
Li, Yafang
Zhou, Yanheng
Qiao, Yiqiang
author_sort Wang, Zao
collection PubMed
description BACKGROUND: Periodontitis is a common disease with an unclear pathological mechanism. No precise consensus has been reached to evaluate the association between the IL-10 rs1800872 (- 592, -590, -597 C>A) polymorphism and periodontal disease. Thus, we performed this meta-analysis to collect more evidence-based information. METHODS: Four online databases, PubMed, Embase, Web of Science, and China Biology Medicine disc (CBM), were searched in August 2018. An odds ratio (OR) with a 95% confidence interval (CI) was applied to evaluate the association of the rs1800872 with periodontitis susceptibility. RESULTS: Twenty three case–control studies with 2714 patients and 2373 healthy controls were evaluated. The overall analyses verified that the IL-10 rs1800872 polymorphism was significantly associated with an increased risk of periodontitis in the allelic model, homozygote model, dominant model, and recessive model (A vs C: OR = 1.28, 95%CI = 1.11–1.49, P = .00, I(2) = 56.87%; AA vs CC: OR = 2.06, 95%CI = 1.32–3.23, P = .00, I(2) = 73.3%; AA + AC vs CC: OR = 1.42, 95%CI = 1.03–1.96, P = .03, I(2) = 76.2%; AA vs AC + CC: OR = 1.78, 95%CI = 1.26–2.56, P = .00, I(2) = 76.7%). Moreover, the subgroup analysis based on ethnicity, periodontitis type, and smoking status showed significant differences. CONCLUSIONS: The results of our meta-analysis demonstrate that rs1800872 is associated with periodontitis susceptibility in Caucasians and Asians. Moreover, A allele, AA genotype, CC genotype may be closely associated with chronic periodontitis (CP), while A allele, AA genotype may be closely associated with aggressive periodontitis (AgP).
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spelling pubmed-67831892019-11-13 Association between the IL-10 rs1800872 polymorphisms and periodontitis susceptibility: A meta-analysis Wang, Zao Li, Yafang Zhou, Yanheng Qiao, Yiqiang Medicine (Baltimore) 5900 BACKGROUND: Periodontitis is a common disease with an unclear pathological mechanism. No precise consensus has been reached to evaluate the association between the IL-10 rs1800872 (- 592, -590, -597 C>A) polymorphism and periodontal disease. Thus, we performed this meta-analysis to collect more evidence-based information. METHODS: Four online databases, PubMed, Embase, Web of Science, and China Biology Medicine disc (CBM), were searched in August 2018. An odds ratio (OR) with a 95% confidence interval (CI) was applied to evaluate the association of the rs1800872 with periodontitis susceptibility. RESULTS: Twenty three case–control studies with 2714 patients and 2373 healthy controls were evaluated. The overall analyses verified that the IL-10 rs1800872 polymorphism was significantly associated with an increased risk of periodontitis in the allelic model, homozygote model, dominant model, and recessive model (A vs C: OR = 1.28, 95%CI = 1.11–1.49, P = .00, I(2) = 56.87%; AA vs CC: OR = 2.06, 95%CI = 1.32–3.23, P = .00, I(2) = 73.3%; AA + AC vs CC: OR = 1.42, 95%CI = 1.03–1.96, P = .03, I(2) = 76.2%; AA vs AC + CC: OR = 1.78, 95%CI = 1.26–2.56, P = .00, I(2) = 76.7%). Moreover, the subgroup analysis based on ethnicity, periodontitis type, and smoking status showed significant differences. CONCLUSIONS: The results of our meta-analysis demonstrate that rs1800872 is associated with periodontitis susceptibility in Caucasians and Asians. Moreover, A allele, AA genotype, CC genotype may be closely associated with chronic periodontitis (CP), while A allele, AA genotype may be closely associated with aggressive periodontitis (AgP). Wolters Kluwer Health 2019-10-04 /pmc/articles/PMC6783189/ /pubmed/31577700 http://dx.doi.org/10.1097/MD.0000000000017113 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle 5900
Wang, Zao
Li, Yafang
Zhou, Yanheng
Qiao, Yiqiang
Association between the IL-10 rs1800872 polymorphisms and periodontitis susceptibility: A meta-analysis
title Association between the IL-10 rs1800872 polymorphisms and periodontitis susceptibility: A meta-analysis
title_full Association between the IL-10 rs1800872 polymorphisms and periodontitis susceptibility: A meta-analysis
title_fullStr Association between the IL-10 rs1800872 polymorphisms and periodontitis susceptibility: A meta-analysis
title_full_unstemmed Association between the IL-10 rs1800872 polymorphisms and periodontitis susceptibility: A meta-analysis
title_short Association between the IL-10 rs1800872 polymorphisms and periodontitis susceptibility: A meta-analysis
title_sort association between the il-10 rs1800872 polymorphisms and periodontitis susceptibility: a meta-analysis
topic 5900
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783189/
https://www.ncbi.nlm.nih.gov/pubmed/31577700
http://dx.doi.org/10.1097/MD.0000000000017113
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