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Association between the IL-10 rs1800872 polymorphisms and periodontitis susceptibility: A meta-analysis
BACKGROUND: Periodontitis is a common disease with an unclear pathological mechanism. No precise consensus has been reached to evaluate the association between the IL-10 rs1800872 (- 592, -590, -597 C>A) polymorphism and periodontal disease. Thus, we performed this meta-analysis to collect more e...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783189/ https://www.ncbi.nlm.nih.gov/pubmed/31577700 http://dx.doi.org/10.1097/MD.0000000000017113 |
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author | Wang, Zao Li, Yafang Zhou, Yanheng Qiao, Yiqiang |
author_facet | Wang, Zao Li, Yafang Zhou, Yanheng Qiao, Yiqiang |
author_sort | Wang, Zao |
collection | PubMed |
description | BACKGROUND: Periodontitis is a common disease with an unclear pathological mechanism. No precise consensus has been reached to evaluate the association between the IL-10 rs1800872 (- 592, -590, -597 C>A) polymorphism and periodontal disease. Thus, we performed this meta-analysis to collect more evidence-based information. METHODS: Four online databases, PubMed, Embase, Web of Science, and China Biology Medicine disc (CBM), were searched in August 2018. An odds ratio (OR) with a 95% confidence interval (CI) was applied to evaluate the association of the rs1800872 with periodontitis susceptibility. RESULTS: Twenty three case–control studies with 2714 patients and 2373 healthy controls were evaluated. The overall analyses verified that the IL-10 rs1800872 polymorphism was significantly associated with an increased risk of periodontitis in the allelic model, homozygote model, dominant model, and recessive model (A vs C: OR = 1.28, 95%CI = 1.11–1.49, P = .00, I(2) = 56.87%; AA vs CC: OR = 2.06, 95%CI = 1.32–3.23, P = .00, I(2) = 73.3%; AA + AC vs CC: OR = 1.42, 95%CI = 1.03–1.96, P = .03, I(2) = 76.2%; AA vs AC + CC: OR = 1.78, 95%CI = 1.26–2.56, P = .00, I(2) = 76.7%). Moreover, the subgroup analysis based on ethnicity, periodontitis type, and smoking status showed significant differences. CONCLUSIONS: The results of our meta-analysis demonstrate that rs1800872 is associated with periodontitis susceptibility in Caucasians and Asians. Moreover, A allele, AA genotype, CC genotype may be closely associated with chronic periodontitis (CP), while A allele, AA genotype may be closely associated with aggressive periodontitis (AgP). |
format | Online Article Text |
id | pubmed-6783189 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-67831892019-11-13 Association between the IL-10 rs1800872 polymorphisms and periodontitis susceptibility: A meta-analysis Wang, Zao Li, Yafang Zhou, Yanheng Qiao, Yiqiang Medicine (Baltimore) 5900 BACKGROUND: Periodontitis is a common disease with an unclear pathological mechanism. No precise consensus has been reached to evaluate the association between the IL-10 rs1800872 (- 592, -590, -597 C>A) polymorphism and periodontal disease. Thus, we performed this meta-analysis to collect more evidence-based information. METHODS: Four online databases, PubMed, Embase, Web of Science, and China Biology Medicine disc (CBM), were searched in August 2018. An odds ratio (OR) with a 95% confidence interval (CI) was applied to evaluate the association of the rs1800872 with periodontitis susceptibility. RESULTS: Twenty three case–control studies with 2714 patients and 2373 healthy controls were evaluated. The overall analyses verified that the IL-10 rs1800872 polymorphism was significantly associated with an increased risk of periodontitis in the allelic model, homozygote model, dominant model, and recessive model (A vs C: OR = 1.28, 95%CI = 1.11–1.49, P = .00, I(2) = 56.87%; AA vs CC: OR = 2.06, 95%CI = 1.32–3.23, P = .00, I(2) = 73.3%; AA + AC vs CC: OR = 1.42, 95%CI = 1.03–1.96, P = .03, I(2) = 76.2%; AA vs AC + CC: OR = 1.78, 95%CI = 1.26–2.56, P = .00, I(2) = 76.7%). Moreover, the subgroup analysis based on ethnicity, periodontitis type, and smoking status showed significant differences. CONCLUSIONS: The results of our meta-analysis demonstrate that rs1800872 is associated with periodontitis susceptibility in Caucasians and Asians. Moreover, A allele, AA genotype, CC genotype may be closely associated with chronic periodontitis (CP), while A allele, AA genotype may be closely associated with aggressive periodontitis (AgP). Wolters Kluwer Health 2019-10-04 /pmc/articles/PMC6783189/ /pubmed/31577700 http://dx.doi.org/10.1097/MD.0000000000017113 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 |
spellingShingle | 5900 Wang, Zao Li, Yafang Zhou, Yanheng Qiao, Yiqiang Association between the IL-10 rs1800872 polymorphisms and periodontitis susceptibility: A meta-analysis |
title | Association between the IL-10 rs1800872 polymorphisms and periodontitis susceptibility: A meta-analysis |
title_full | Association between the IL-10 rs1800872 polymorphisms and periodontitis susceptibility: A meta-analysis |
title_fullStr | Association between the IL-10 rs1800872 polymorphisms and periodontitis susceptibility: A meta-analysis |
title_full_unstemmed | Association between the IL-10 rs1800872 polymorphisms and periodontitis susceptibility: A meta-analysis |
title_short | Association between the IL-10 rs1800872 polymorphisms and periodontitis susceptibility: A meta-analysis |
title_sort | association between the il-10 rs1800872 polymorphisms and periodontitis susceptibility: a meta-analysis |
topic | 5900 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783189/ https://www.ncbi.nlm.nih.gov/pubmed/31577700 http://dx.doi.org/10.1097/MD.0000000000017113 |
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