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Structural mapping of oligomeric intermediates in an amyloid assembly pathway

Transient oligomers are commonly formed in the early stages of amyloid assembly. Determining the structure(s) of these species and defining their role(s) in assembly is key to devising new routes to control disease. Here, using a combination of chemical kinetics, NMR spectroscopy and other biophysic...

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Detalles Bibliográficos
Autores principales:	Karamanos, Theodoros K, Jackson, Matthew P, Calabrese, Antonio N, Goodchild, Sophia C, Cawood, Emma E, Thompson, Gary S, Kalverda, Arnout P, Hewitt, Eric W, Radford, Sheena E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Structural Biology and Molecular Biophysics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783270/ https://www.ncbi.nlm.nih.gov/pubmed/31552823 http://dx.doi.org/10.7554/eLife.46574

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