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Structure of ribosome-bound azole-modified peptide phazolicin rationalizes its species-specific mode of bacterial translation inhibition

Ribosome-synthesized post-translationally modified peptides (RiPPs) represent a rapidly expanding class of natural products with various biological activities. Linear azol(in)e-containing peptides (LAPs) comprise a subclass of RiPPs that display outstanding diversity of mechanisms of action while sh...

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Detalles Bibliográficos
Autores principales: Travin, Dmitrii Y., Watson, Zoe L., Metelev, Mikhail, Ward, Fred R., Osterman, Ilya A., Khven, Irina M., Khabibullina, Nelli F., Serebryakova, Marina, Mergaert, Peter, Polikanov, Yury S., Cate, Jamie H. D., Severinov, Konstantin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783444/
https://www.ncbi.nlm.nih.gov/pubmed/31594941
http://dx.doi.org/10.1038/s41467-019-12589-5