Cargando…
Structure of ribosome-bound azole-modified peptide phazolicin rationalizes its species-specific mode of bacterial translation inhibition
Ribosome-synthesized post-translationally modified peptides (RiPPs) represent a rapidly expanding class of natural products with various biological activities. Linear azol(in)e-containing peptides (LAPs) comprise a subclass of RiPPs that display outstanding diversity of mechanisms of action while sh...
Autores principales: | Travin, Dmitrii Y., Watson, Zoe L., Metelev, Mikhail, Ward, Fred R., Osterman, Ilya A., Khven, Irina M., Khabibullina, Nelli F., Serebryakova, Marina, Mergaert, Peter, Polikanov, Yury S., Cate, Jamie H. D., Severinov, Konstantin |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783444/ https://www.ncbi.nlm.nih.gov/pubmed/31594941 http://dx.doi.org/10.1038/s41467-019-12589-5 |
Ejemplares similares
-
Klebsazolicin inhibits 70S ribosome by obstruction of the peptide exit tunnel
por: Metelev, Mikhail, et al.
Publicado: (2017) -
Dual-Uptake Mode of the Antibiotic Phazolicin Prevents Resistance Acquisition by Gram-Negative Bacteria
por: Travin, Dmitrii Y., et al.
Publicado: (2023) -
Complete Genome Sequences of Two Rhizobium Strains Producing Azol(in)e-Modified Antibiotics
por: Travin, Dmitrii Y., et al.
Publicado: (2022) -
Architecture of Microcin B17 Synthetase: An Octameric Protein Complex Converting a Ribosomally Synthesized Peptide into a DNA Gyrase Poison
por: Ghilarov, Dmitry, et al.
Publicado: (2019) -
Mechanistic insights into the slow peptide bond formation with D-amino acids in the ribosomal active site
por: Melnikov, Sergey V, et al.
Publicado: (2019)