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Neural correlates of positive and negative symptoms through the illness course: an fMRI study in early psychosis and chronic schizophrenia

Psychotic illness is associated with cognitive control deficits and abnormal recruitment of neural circuits subserving cognitive control. It is unclear to what extent this dysfunction underlies the development and/or maintenance of positive and negative symptoms typically observed in schizophrenia....

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Autores principales: Vanes, Lucy D., Mouchlianitis, Elias, Patel, Krisna, Barry, Erica, Wong, Katie, Thomas, Megan, Szentgyorgyi, Timea, Joyce, Dan, Shergill, Sukhwinder
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783468/
https://www.ncbi.nlm.nih.gov/pubmed/31595009
http://dx.doi.org/10.1038/s41598-019-51023-0
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author Vanes, Lucy D.
Mouchlianitis, Elias
Patel, Krisna
Barry, Erica
Wong, Katie
Thomas, Megan
Szentgyorgyi, Timea
Joyce, Dan
Shergill, Sukhwinder
author_facet Vanes, Lucy D.
Mouchlianitis, Elias
Patel, Krisna
Barry, Erica
Wong, Katie
Thomas, Megan
Szentgyorgyi, Timea
Joyce, Dan
Shergill, Sukhwinder
author_sort Vanes, Lucy D.
collection PubMed
description Psychotic illness is associated with cognitive control deficits and abnormal recruitment of neural circuits subserving cognitive control. It is unclear to what extent this dysfunction underlies the development and/or maintenance of positive and negative symptoms typically observed in schizophrenia. In this study we compared fMRI activation on a standard Stroop task and its relationship with positive and negative symptoms in early psychosis (EP, N = 88) and chronic schizophrenia (CHR-SZ, N = 38) patients. CHR-SZ patients showed reduced frontal, striatal, and parietal activation across incongruent and congruent trials compared to EP patients. Higher positive symptom severity was associated with reduced activation across both trial types in supplementary motor area (SMA), middle temporal gyrus and cerebellum in EP, but not CHR-SZ patients. Higher negative symptom severity was associated with reduced cerebellar activation in EP, but not in CHR-SZ patients. A negative correlation between negative symptoms and activation in SMA and precentral gyrus was observed in EP patients and in CHR-SZ patients. The results suggest that the neural substrate of positive symptoms changes with illness chronicity, and that cognitive control related neural circuits may be most relevant in the initial development phase of positive symptoms. These findings also highlight a changing role for the cerebellum in the development and later maintenance of both positive and negative symptoms.
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spelling pubmed-67834682019-10-16 Neural correlates of positive and negative symptoms through the illness course: an fMRI study in early psychosis and chronic schizophrenia Vanes, Lucy D. Mouchlianitis, Elias Patel, Krisna Barry, Erica Wong, Katie Thomas, Megan Szentgyorgyi, Timea Joyce, Dan Shergill, Sukhwinder Sci Rep Article Psychotic illness is associated with cognitive control deficits and abnormal recruitment of neural circuits subserving cognitive control. It is unclear to what extent this dysfunction underlies the development and/or maintenance of positive and negative symptoms typically observed in schizophrenia. In this study we compared fMRI activation on a standard Stroop task and its relationship with positive and negative symptoms in early psychosis (EP, N = 88) and chronic schizophrenia (CHR-SZ, N = 38) patients. CHR-SZ patients showed reduced frontal, striatal, and parietal activation across incongruent and congruent trials compared to EP patients. Higher positive symptom severity was associated with reduced activation across both trial types in supplementary motor area (SMA), middle temporal gyrus and cerebellum in EP, but not CHR-SZ patients. Higher negative symptom severity was associated with reduced cerebellar activation in EP, but not in CHR-SZ patients. A negative correlation between negative symptoms and activation in SMA and precentral gyrus was observed in EP patients and in CHR-SZ patients. The results suggest that the neural substrate of positive symptoms changes with illness chronicity, and that cognitive control related neural circuits may be most relevant in the initial development phase of positive symptoms. These findings also highlight a changing role for the cerebellum in the development and later maintenance of both positive and negative symptoms. Nature Publishing Group UK 2019-10-08 /pmc/articles/PMC6783468/ /pubmed/31595009 http://dx.doi.org/10.1038/s41598-019-51023-0 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Vanes, Lucy D.
Mouchlianitis, Elias
Patel, Krisna
Barry, Erica
Wong, Katie
Thomas, Megan
Szentgyorgyi, Timea
Joyce, Dan
Shergill, Sukhwinder
Neural correlates of positive and negative symptoms through the illness course: an fMRI study in early psychosis and chronic schizophrenia
title Neural correlates of positive and negative symptoms through the illness course: an fMRI study in early psychosis and chronic schizophrenia
title_full Neural correlates of positive and negative symptoms through the illness course: an fMRI study in early psychosis and chronic schizophrenia
title_fullStr Neural correlates of positive and negative symptoms through the illness course: an fMRI study in early psychosis and chronic schizophrenia
title_full_unstemmed Neural correlates of positive and negative symptoms through the illness course: an fMRI study in early psychosis and chronic schizophrenia
title_short Neural correlates of positive and negative symptoms through the illness course: an fMRI study in early psychosis and chronic schizophrenia
title_sort neural correlates of positive and negative symptoms through the illness course: an fmri study in early psychosis and chronic schizophrenia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783468/
https://www.ncbi.nlm.nih.gov/pubmed/31595009
http://dx.doi.org/10.1038/s41598-019-51023-0
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