Dimethylaminomicheliolide (DMAMCL) Suppresses the Proliferation of Glioblastoma Cells via Targeting Pyruvate Kinase 2 (PKM2) and Rewiring Aerobic Glycolysis

Glioblastoma (GBM) is the most prevalent malignant tumor in the central nervous system. Aerobic glycolysis, featured with elevated glucose consumption and lactate production, confers selective advantages on GBM by utilizing nutrients to support rapid cell proliferation and tumor growth. Pyruvate kin...

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Detalles Bibliográficos
Autores principales: Guo, Jianshuang, Xue, Qingqing, Liu, Kaihui, Ge, Weizhi, Liu, Wenjie, Wang, Jiyan, Zhang, Mengyi, Li, Qiu-ying, Cai, Dongpo, Shan, Changliang, Zhang, Chunze, Liu, Xinqi, Li, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783512/
https://www.ncbi.nlm.nih.gov/pubmed/31632919
http://dx.doi.org/10.3389/fonc.2019.00993

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