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HIF1α inhibition facilitates Leflunomide-AHR-CRP signaling to attenuate bone erosion in CRP-aberrant rheumatoid arthritis

Rheumatoid arthritis (RA) is a chronic inflammatory disorder characterized by progressive bone erosion. Leflunomide is originally developed to suppress inflammation via its metabolite A77 1726 to attenuate bone erosion. However, distinctive responsiveness to Leflunomide is observed among RA individu...

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Detalles Bibliográficos
Autores principales:	Liang, Chao, Li, Jie, Lu, Cheng, Xie, Duoli, Liu, Jin, Zhong, Chuanxin, Wu, Xiaohao, Dai, Rongchen, Zhang, Huarui, Guan, Daogang, Guo, Baosheng, He, Bing, Li, Fangfei, He, Xiaojuan, Zhang, Wandong, Zhang, Bao-Ting, Zhang, Ge, Lu, Aiping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783548/ https://www.ncbi.nlm.nih.gov/pubmed/31594926 http://dx.doi.org/10.1038/s41467-019-12163-z

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