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SCALE method for single-cell ATAC-seq analysis via latent feature extraction

Single-cell ATAC-seq (scATAC-seq) profiles the chromatin accessibility landscape at single cell level, thus revealing cell-to-cell variability in gene regulation. However, the high dimensionality and sparsity of scATAC-seq data often complicate the analysis. Here, we introduce a method for analyzing...

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Detalles Bibliográficos
Autores principales:	Xiong, Lei, Xu, Kui, Tian, Kang, Shao, Yanqiu, Tang, Lei, Gao, Ge, Zhang, Michael, Jiang, Tao, Zhang, Qiangfeng Cliff
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783552/ https://www.ncbi.nlm.nih.gov/pubmed/31594952 http://dx.doi.org/10.1038/s41467-019-12630-7

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