Airway epithelial cell isolation techniques affect DNA methylation profiles with consequences for analysis of asthma related perturbations to DNA methylation

The airway epithelium forms the interface between the inhaled environment and the lung. The airway epithelium is dysfunctional in asthma and epigenetic mechanisms are considered a contributory factor. We hypothesised that the DNA methylation profiles of cultured primary airway epithelial cells (AECs...

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Detalles Bibliográficos
Autores principales: Clifford, Rachel L., Patel, Jamie, MacIsaac, Julia L., McEwen, Lisa M., Johnson, Simon R., Shaw, Dominick, Knox, Alan J., Hackett, Tillie-Louise, Kobor, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783553/
https://www.ncbi.nlm.nih.gov/pubmed/31595000
http://dx.doi.org/10.1038/s41598-019-50873-y

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