NFκB/Orai1 Facilitates Endoplasmic Reticulum Stress by Oxidative Stress in the Pathogenesis of Non-alcoholic Fatty Liver Disease

Non-esterified fatty acids (NEFAs) promote de novo lipogenesis, which caused abnormal hepatic lipid accumulation, by the NFκB–Orai1 pathway. Oxidative stress and endoplasmic reticulum (ER) stress have been recognized as key mechanisms in non-alcoholic fatty liver disease (NAFLD) pathogenesis. Whethe...

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Detalles Bibliográficos
Autores principales: Zhang, Bingbing, Li, Ming, Zou, Ying, Guo, Han, Zhang, Bingdong, Xia, Cheng, Zhang, Hongyou, Yang, Wei, Xu, Chuang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783633/
https://www.ncbi.nlm.nih.gov/pubmed/31632961
http://dx.doi.org/10.3389/fcell.2019.00202

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