TIP30 counteracts cardiac hypertrophy and failure by inhibiting translational elongation

Pathological cardiac overload induces myocardial protein synthesis and hypertrophy, which predisposes to heart failure. To inhibit hypertrophy therapeutically, the identification of negative regulators of cardiomyocyte protein synthesis is needed. Here, we identified the tumor suppressor protein TIP...

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Detalles Bibliográficos
Autores principales: Grund, Andrea, Szaroszyk, Malgorzata, Korf‐Klingebiel, Mortimer, Malek Mohammadi, Mona, Trogisch, Felix A, Schrameck, Ulrike, Gigina, Anna, Tiedje, Christopher, Gaestel, Matthias, Kraft, Theresia, Hegermann, Jan, Batkai, Sandor, Thum, Thomas, Perrot, Andreas, dos Remedios, Cris, Riechert, Eva, Völkers, Mirko, Doroudgar, Shirin, Jungmann, Andreas, Bauer, Ralf, Yin, Xiaoke, Mayr, Manuel, Wollert, Kai C, Pich, Andreas, Xiao, Hua, Katus, Hugo A, Bauersachs, Johann, Müller, Oliver J, Heineke, Joerg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783653/
https://www.ncbi.nlm.nih.gov/pubmed/31468715
http://dx.doi.org/10.15252/emmm.201810018

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