HBV cccDNA and Its Potential as a Therapeutic Target

Chronic hepatitis B virus infection continues to be a major health burden worldwide. It can cause various degrees of liver damage and is strongly associated with the development of liver cirrhosis and hepatocellular carcinoma. Covalently closed circular DNA in the nucleus of infected cells cannot be...

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Detalles Bibliográficos
Autores principales: Zhu, Anjing, Liao, Xinzhong, Li, Shuang, Zhao, Hang, Chen, Limin, Xu, Min, Duan, Xiaoqiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: XIA & HE Publishing Inc. 2019
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783673/
https://www.ncbi.nlm.nih.gov/pubmed/31608218
http://dx.doi.org/10.14218/JCTH.2018.00054
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author Zhu, Anjing
Liao, Xinzhong
Li, Shuang
Zhao, Hang
Chen, Limin
Xu, Min
Duan, Xiaoqiong
author_facet Zhu, Anjing
Liao, Xinzhong
Li, Shuang
Zhao, Hang
Chen, Limin
Xu, Min
Duan, Xiaoqiong
author_sort Zhu, Anjing
collection PubMed
description Chronic hepatitis B virus infection continues to be a major health burden worldwide. It can cause various degrees of liver damage and is strongly associated with the development of liver cirrhosis and hepatocellular carcinoma. Covalently closed circular DNA in the nucleus of infected cells cannot be disabled by present therapies which may lead to HBV persistence and relapse. In this review, we summarized the current knowledge on hepatitis B virus covalently closed circular DNA and its potential role as a therapeutic target.
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spelling pubmed-67836732019-10-11 HBV cccDNA and Its Potential as a Therapeutic Target Zhu, Anjing Liao, Xinzhong Li, Shuang Zhao, Hang Chen, Limin Xu, Min Duan, Xiaoqiong J Clin Transl Hepatol Review Article Chronic hepatitis B virus infection continues to be a major health burden worldwide. It can cause various degrees of liver damage and is strongly associated with the development of liver cirrhosis and hepatocellular carcinoma. Covalently closed circular DNA in the nucleus of infected cells cannot be disabled by present therapies which may lead to HBV persistence and relapse. In this review, we summarized the current knowledge on hepatitis B virus covalently closed circular DNA and its potential role as a therapeutic target. XIA & HE Publishing Inc. 2019-07-31 2019-09-28 /pmc/articles/PMC6783673/ /pubmed/31608218 http://dx.doi.org/10.14218/JCTH.2018.00054 Text en © 2019 Authors. http://creativecommons.org/licenses/by-nc/4.0/ This article has been published under the terms of Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0), which permits noncommercial unrestricted use, distribution, and reproduction in any medium, provided that the following statement is provided. “This article has been published in Journal of Clinical and Translational Hepatology at DOI: 10.14218/JCTH.2018.00054 and can also be viewed on the Journal’s website at http://www.jcthnet.com”.
spellingShingle Review Article
Zhu, Anjing
Liao, Xinzhong
Li, Shuang
Zhao, Hang
Chen, Limin
Xu, Min
Duan, Xiaoqiong
HBV cccDNA and Its Potential as a Therapeutic Target
title HBV cccDNA and Its Potential as a Therapeutic Target
title_full HBV cccDNA and Its Potential as a Therapeutic Target
title_fullStr HBV cccDNA and Its Potential as a Therapeutic Target
title_full_unstemmed HBV cccDNA and Its Potential as a Therapeutic Target
title_short HBV cccDNA and Its Potential as a Therapeutic Target
title_sort hbv cccdna and its potential as a therapeutic target
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783673/
https://www.ncbi.nlm.nih.gov/pubmed/31608218
http://dx.doi.org/10.14218/JCTH.2018.00054
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