Cargando…

Bitter Taste Receptors (TAS2Rs) in Human Lung Macrophages: Receptor Expression and Inhibitory Effects of TAS2R Agonists

BACKGROUND: Bitter-taste receptors (TAS2Rs) are involved in airway relaxation but are also expressed in human blood leukocytes. We studied TAS2R expression and the effects of TAS2R agonists on the lipopolysaccharide (LPS)-induced cytokine release in human lung macrophages (LMs). METHODS: Lung macrop...

Descripción completa

Detalles Bibliográficos
Autores principales:	Grassin-Delyle, Stanislas, Salvator, Hélène, Mantov, Nikola, Abrial, Charlotte, Brollo, Marion, Faisy, Christophe, Naline, Emmanuel, Couderc, Louis-Jean, Devillier, Philippe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783802/ https://www.ncbi.nlm.nih.gov/pubmed/31632299 http://dx.doi.org/10.3389/fphys.2019.01267

Ejemplares similares

The expression and relaxant effect of bitter taste receptors in human bronchi
por: Grassin-Delyle, Stanislas, et al.
Publicado: (2013)

Adiponectin Inhibits the Production of TNF-α, IL-6 and Chemokines by Human Lung Macrophages
por: Salvator, Hélène, et al.
Publicado: (2021)

Human lung and monocyte-derived macrophages differ with regard to the effects of β(2)-adrenoceptor agonists on cytokine release
por: Victoni, Tatiana, et al.
Publicado: (2017)

Ruxolitinib inhibits cytokine production by human lung macrophages without impairing phagocytic ability
por: Mantov, Nikola, et al.
Publicado: (2022)

Construction of a bioluminescence-based assay for bitter taste receptors (TAS2Rs)
por: Tan, Shi Min, et al.
Publicado: (2022)

Contrasting Effects of Adipokines on the Cytokine Production by Primary Human Bronchial Epithelial Cells: Inhibitory Effects of Adiponectin
por: Salvator, Hélène, et al.
Publicado: (2020)

Vanillin Activates Human Bitter Taste Receptors TAS2R14, TAS2R20, and TAS2R39
por: Morini, Gabriella, et al.
Publicado: (2021)

Clinical Relevance of the Anti-inflammatory Effects of Roflumilast on Human Bronchus: Potentiation by a Long-Acting Beta-2-Agonist
por: Salvator, Hélène, et al.
Publicado: (2020)

Wnt/β-Catenin Signaling Modulates Human Airway Sensitization Induced by β(2)-Adrenoceptor Stimulation
por: Faisy, Christophe, et al.
Publicado: (2014)

TAS2R38 bitter taste receptor and attainment of exceptional longevity
por: Melis, Melania, et al.
Publicado: (2019)

A marine-sourced fucoidan solution inhibits Toll-like-receptor-3-induced cytokine release by human bronchial epithelial cells
por: Dutot, M., et al.
Publicado: (2019)

6-Methoxyflavanones as Bitter Taste Receptor Blockers for hTAS2R39
por: Roland, Wibke S. U., et al.
Publicado: (2014)

Genetic Variation in the TAS2R38 Bitter Taste Receptor and Smoking Behaviors
por: Risso, Davide S., et al.
Publicado: (2016)

Global population genetics and diversity in the TAS2R bitter taste receptor family
por: Wooding, Stephen P., et al.
Publicado: (2022)

Eco-Geographical Diversification of Bitter Taste Receptor Genes (TAS2Rs) among Subspecies of Chimpanzees (Pan troglodytes)
por: Hayakawa, Takashi, et al.
Publicado: (2012)

Activation of bitter taste receptors (tas2rs) relaxes detrusor smooth muscle and suppresses overactive bladder symptoms
por: Zhai, Kui, et al.
Publicado: (2016)

Variation in ligand responses of the bitter taste receptors TAS2R1 and TAS2R4 among New World monkeys
por: Tsutsui, Kei, et al.
Publicado: (2016)

Effectiveness of a Load-Imposing Device for Cyclic Stretching of Isolated Human Bronchi: A Validation Study
por: Le Guen, Morgan, et al.
Publicado: (2015)

Probenecid Inhibits the Human Bitter Taste Receptor TAS2R16 and Suppresses Bitter Perception of Salicin
por: Greene, Tiffani A., et al.
Publicado: (2011)

Impact of sweet, umami, and bitter taste receptor (TAS1R and TAS2R) genomic and expression alterations in solid tumors on survival
por: Carey, Ryan M., et al.
Publicado: (2022)

TAS2R38 taste receptor gene and chronic rhinosinusitis: a bitter ending
por: Montrasio, Giulia, et al.
Publicado: (2015)

The effect of MP29-02* is mediated via bitter taste receptors (TAS2R)
por: Ekstedt, Sandra, et al.
Publicado: (2015)

Effects of MP-AzeFlu enhanced by activation of bitter taste receptor TAS2R
por: Ekstedt, Sandra, et al.
Publicado: (2020)

Bitter taste receptor (TAS2R) 46 in human skeletal muscle: expression and activity
por: Talmon, Maria, et al.
Publicado: (2023)

The impact of low-frequency, low-force cyclic stretching of human bronchi on airway responsiveness
por: Le Guen, Morgan, et al.
Publicado: (2016)

Members of Bitter Taste Receptor Cluster Tas2r143/Tas2r135/Tas2r126 Are Expressed in the Epithelium of Murine Airways and Other Non-gustatory Tissues
por: Liu, Shuya, et al.
Publicado: (2017)

Predicted structure of fully activated human bitter taste receptor TAS2R4 complexed with G protein and agonists
por: Yang, Moon Young, et al.
Publicado: (2021)

Anti-cancer stemness and anti-invasive activity of bitter taste receptors, TAS2R8 and TAS2R10, in human neuroblastoma cells
por: Seo, Yoona, et al.
Publicado: (2017)

Genetic Variation in the TAS2R38 Bitter Taste Receptor and Gastric Cancer Risk in Koreans
por: Choi, Jeong-Hwa, et al.
Publicado: (2016)

A Subset of Mouse Colonic Goblet Cells Expresses the Bitter Taste Receptor Tas2r131
por: Prandi, Simone, et al.
Publicado: (2013)

Global diversity in the TAS2R38 bitter taste receptor: revisiting a classic evolutionary PROPosal
por: Risso, Davide S., et al.
Publicado: (2016)

Distribution of TAS2R38 bitter taste receptor phenotype and haplotypes among COVID-19 patients
por: Risso, D., et al.
Publicado: (2022)

Bitter Taste Receptor TAS2R38 Genetic Variation (rs10246939), Dietary Nutrient Intake, and Bio-Clinical Parameters in Koreans
por: Benish,, et al.
Publicado: (2023)

Coarse-Grained/Molecular Mechanics of the TAS2R38 Bitter Taste Receptor: Experimentally-Validated Detailed Structural Prediction of Agonist Binding
por: Marchiori, Alessandro, et al.
Publicado: (2013)

Bitter Peptides YFYPEL, VAPFPEVF, and YQEPVLGPVRGPFPIIV, Released during Gastric Digestion of Casein, Stimulate Mechanisms of Gastric Acid Secretion via Bitter Taste Receptors TAS2R16 and TAS2R38
por: Richter, Phil, et al.
Publicado: (2022)

A functional comparison of the domestic cat bitter receptors Tas2r38 and Tas2r43 with their human orthologs
por: Sandau, Michelle M, et al.
Publicado: (2015)

Characterization of the β-d-Glucopyranoside Binding Site of the Human Bitter Taste Receptor hTAS2R16
por: Sakurai, Takanobu, et al.
Publicado: (2010)

Corrigendum: Global diversity in the TAS2R38 bitter taste receptor: revisiting a classic evolutionary PROPosal
por: Risso, Davide S., et al.
Publicado: (2016)

Amino acid residues of bitter taste receptor TAS2R16 that determine sensitivity in primates to β-glycosides
por: Imai, Hiroo, et al.
Publicado: (2016)

The influence of bitter-taste receptor (TAS2R) expression in pharmacological response to Chloroquine in obese patients with COVID-19
por: Watanabe, Lígia Moriguchi, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_o8ssf53hlkpm65ks6dt2a63796