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Medical Outcomes in Women Who Became Pregnant after Vaccination with a Virus-Like Particle Experimental Vaccine against Influenza A (H1N1) 2009 Virus Tested during 2009 Pandemic Outbreak

The clinical effects and immunological response to the influenza vaccine in women who later become pregnant remain to be thoroughly studied. Here, we report the medical outcomes of 40 women volunteers who became pregnant after vaccination with an experimental virus-like particle (VLP) vaccine agains...

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Autores principales: Cérbulo-Vázquez, Arturo, Arriaga-Pizano, Lourdes, Cruz-Cureño, Gabriela, Boscó-Gárate, Ilka, Ferat-Osorio, Eduardo, Pastelin-Palacios, Rodolfo, Figueroa-Damian, Ricardo, Castro-Eguiluz, Denisse, Mancilla-Ramirez, Javier, Isibasi, Armando, López-Macías, Constantino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783846/
https://www.ncbi.nlm.nih.gov/pubmed/31533277
http://dx.doi.org/10.3390/v11090868
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author Cérbulo-Vázquez, Arturo
Arriaga-Pizano, Lourdes
Cruz-Cureño, Gabriela
Boscó-Gárate, Ilka
Ferat-Osorio, Eduardo
Pastelin-Palacios, Rodolfo
Figueroa-Damian, Ricardo
Castro-Eguiluz, Denisse
Mancilla-Ramirez, Javier
Isibasi, Armando
López-Macías, Constantino
author_facet Cérbulo-Vázquez, Arturo
Arriaga-Pizano, Lourdes
Cruz-Cureño, Gabriela
Boscó-Gárate, Ilka
Ferat-Osorio, Eduardo
Pastelin-Palacios, Rodolfo
Figueroa-Damian, Ricardo
Castro-Eguiluz, Denisse
Mancilla-Ramirez, Javier
Isibasi, Armando
López-Macías, Constantino
author_sort Cérbulo-Vázquez, Arturo
collection PubMed
description The clinical effects and immunological response to the influenza vaccine in women who later become pregnant remain to be thoroughly studied. Here, we report the medical outcomes of 40 women volunteers who became pregnant after vaccination with an experimental virus-like particle (VLP) vaccine against pandemic influenza A(H1N1)2009 (influenza A(H1N1)pdm09) and their infants. When included in the VLP vaccine trial, none of the women were pregnant and were randomly assigned to one of the following groups: (1) placebo, (2) 15 μg dose of VLP vaccine, or (3) 45 μg dose of VLP vaccine. These 40 women reported becoming pregnant during the follow-up phase after receiving the placebo or VLP vaccine. Women were monitored throughout pregnancy and their infants were monitored until one year after birth. Antibody titers against VLP were measured in the mothers and infants at delivery and at six months and one year after birth. The incidence of preeclampsia, fetal death, preterm delivery, and premature rupture of membranes was similar among groups. All vaccinated women and their infants elicited antibody titers (≥1:40). Women vaccinated prior to pregnancy had no adverse events that were different from the nonvaccinated population. Even though this study is limited by the sample size, the results suggest that the anti-influenza A(H1N1)pdm09 VLP experimental vaccine applied before pregnancy is safe for both mothers and their infants.
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spelling pubmed-67838462019-10-16 Medical Outcomes in Women Who Became Pregnant after Vaccination with a Virus-Like Particle Experimental Vaccine against Influenza A (H1N1) 2009 Virus Tested during 2009 Pandemic Outbreak Cérbulo-Vázquez, Arturo Arriaga-Pizano, Lourdes Cruz-Cureño, Gabriela Boscó-Gárate, Ilka Ferat-Osorio, Eduardo Pastelin-Palacios, Rodolfo Figueroa-Damian, Ricardo Castro-Eguiluz, Denisse Mancilla-Ramirez, Javier Isibasi, Armando López-Macías, Constantino Viruses Article The clinical effects and immunological response to the influenza vaccine in women who later become pregnant remain to be thoroughly studied. Here, we report the medical outcomes of 40 women volunteers who became pregnant after vaccination with an experimental virus-like particle (VLP) vaccine against pandemic influenza A(H1N1)2009 (influenza A(H1N1)pdm09) and their infants. When included in the VLP vaccine trial, none of the women were pregnant and were randomly assigned to one of the following groups: (1) placebo, (2) 15 μg dose of VLP vaccine, or (3) 45 μg dose of VLP vaccine. These 40 women reported becoming pregnant during the follow-up phase after receiving the placebo or VLP vaccine. Women were monitored throughout pregnancy and their infants were monitored until one year after birth. Antibody titers against VLP were measured in the mothers and infants at delivery and at six months and one year after birth. The incidence of preeclampsia, fetal death, preterm delivery, and premature rupture of membranes was similar among groups. All vaccinated women and their infants elicited antibody titers (≥1:40). Women vaccinated prior to pregnancy had no adverse events that were different from the nonvaccinated population. Even though this study is limited by the sample size, the results suggest that the anti-influenza A(H1N1)pdm09 VLP experimental vaccine applied before pregnancy is safe for both mothers and their infants. MDPI 2019-09-17 /pmc/articles/PMC6783846/ /pubmed/31533277 http://dx.doi.org/10.3390/v11090868 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cérbulo-Vázquez, Arturo
Arriaga-Pizano, Lourdes
Cruz-Cureño, Gabriela
Boscó-Gárate, Ilka
Ferat-Osorio, Eduardo
Pastelin-Palacios, Rodolfo
Figueroa-Damian, Ricardo
Castro-Eguiluz, Denisse
Mancilla-Ramirez, Javier
Isibasi, Armando
López-Macías, Constantino
Medical Outcomes in Women Who Became Pregnant after Vaccination with a Virus-Like Particle Experimental Vaccine against Influenza A (H1N1) 2009 Virus Tested during 2009 Pandemic Outbreak
title Medical Outcomes in Women Who Became Pregnant after Vaccination with a Virus-Like Particle Experimental Vaccine against Influenza A (H1N1) 2009 Virus Tested during 2009 Pandemic Outbreak
title_full Medical Outcomes in Women Who Became Pregnant after Vaccination with a Virus-Like Particle Experimental Vaccine against Influenza A (H1N1) 2009 Virus Tested during 2009 Pandemic Outbreak
title_fullStr Medical Outcomes in Women Who Became Pregnant after Vaccination with a Virus-Like Particle Experimental Vaccine against Influenza A (H1N1) 2009 Virus Tested during 2009 Pandemic Outbreak
title_full_unstemmed Medical Outcomes in Women Who Became Pregnant after Vaccination with a Virus-Like Particle Experimental Vaccine against Influenza A (H1N1) 2009 Virus Tested during 2009 Pandemic Outbreak
title_short Medical Outcomes in Women Who Became Pregnant after Vaccination with a Virus-Like Particle Experimental Vaccine against Influenza A (H1N1) 2009 Virus Tested during 2009 Pandemic Outbreak
title_sort medical outcomes in women who became pregnant after vaccination with a virus-like particle experimental vaccine against influenza a (h1n1) 2009 virus tested during 2009 pandemic outbreak
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783846/
https://www.ncbi.nlm.nih.gov/pubmed/31533277
http://dx.doi.org/10.3390/v11090868
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