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Antibiotic-Resistant Septicemia in Pediatric Oncology Patients Associated with Post-Therapeutic Neutropenic Fever

Death in cancer patients can be caused by the progression of tumors, their malignity, or other associated conditions such as sepsis, which is a multiphasic host response to a pathogen that can be significantly amplified by endogenous factors. Its incidence is continuously rising, which reflects the...

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Autores principales: Vázquez-López, Rosalino, Rivero Rojas, Omar, Ibarra Moreno, Andrea, Urrutia Favila, José Erik, Peña Barreto, Adan, Ortega Ortuño, Guadalupe Lizeth, Abello Vaamonde, Jorge Andrés, Aguilar Velazco, Ivanka Alejandra, Félix Castro, José Marcos, Solano-Gálvez, Sandra Georgina, Barrientos Fortes, Tomás, González-Barrios, Juan Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783913/
https://www.ncbi.nlm.nih.gov/pubmed/31366110
http://dx.doi.org/10.3390/antibiotics8030106
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author Vázquez-López, Rosalino
Rivero Rojas, Omar
Ibarra Moreno, Andrea
Urrutia Favila, José Erik
Peña Barreto, Adan
Ortega Ortuño, Guadalupe Lizeth
Abello Vaamonde, Jorge Andrés
Aguilar Velazco, Ivanka Alejandra
Félix Castro, José Marcos
Solano-Gálvez, Sandra Georgina
Barrientos Fortes, Tomás
González-Barrios, Juan Antonio
author_facet Vázquez-López, Rosalino
Rivero Rojas, Omar
Ibarra Moreno, Andrea
Urrutia Favila, José Erik
Peña Barreto, Adan
Ortega Ortuño, Guadalupe Lizeth
Abello Vaamonde, Jorge Andrés
Aguilar Velazco, Ivanka Alejandra
Félix Castro, José Marcos
Solano-Gálvez, Sandra Georgina
Barrientos Fortes, Tomás
González-Barrios, Juan Antonio
author_sort Vázquez-López, Rosalino
collection PubMed
description Death in cancer patients can be caused by the progression of tumors, their malignity, or other associated conditions such as sepsis, which is a multiphasic host response to a pathogen that can be significantly amplified by endogenous factors. Its incidence is continuously rising, which reflects the increasing number of sick patients at a higher risk of infection, especially those that are elderly, pediatric, or immunosuppressed. Sepsis appears to be directly associated with oncological treatment and fatal septic shock. Patients with a cancer diagnosis face a much higher risk of infections after being immunosuppressed by chemotherapy, radiotherapy, or anti-inflammatory therapy, especially caused by non-pathogenic, Gram-negative, and multidrug-resistant pathogens. There is a notorious difference between the incidence and mortality rates related to sepsis in pediatric oncologic patients between developed and developing countries: they are much higher in developing countries, where investment for diagnosis and treatment resources, infrastructure, medical specialists, cancer-related control programs, and post-therapeutic care is insufficient. This situation not only limits but also reduces the life expectancy of treated pediatric oncologic patients, and demands higher costs from the healthcare systems. Therefore, efforts must aim to limit the progression of sepsis conditions, applying the most recommended therapeutic regimens as soon as the initial risk factors are clinically evident—or even before they are, as when taking advantage of machine learning prediction systems to analyze data.
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spelling pubmed-67839132019-10-16 Antibiotic-Resistant Septicemia in Pediatric Oncology Patients Associated with Post-Therapeutic Neutropenic Fever Vázquez-López, Rosalino Rivero Rojas, Omar Ibarra Moreno, Andrea Urrutia Favila, José Erik Peña Barreto, Adan Ortega Ortuño, Guadalupe Lizeth Abello Vaamonde, Jorge Andrés Aguilar Velazco, Ivanka Alejandra Félix Castro, José Marcos Solano-Gálvez, Sandra Georgina Barrientos Fortes, Tomás González-Barrios, Juan Antonio Antibiotics (Basel) Review Death in cancer patients can be caused by the progression of tumors, their malignity, or other associated conditions such as sepsis, which is a multiphasic host response to a pathogen that can be significantly amplified by endogenous factors. Its incidence is continuously rising, which reflects the increasing number of sick patients at a higher risk of infection, especially those that are elderly, pediatric, or immunosuppressed. Sepsis appears to be directly associated with oncological treatment and fatal septic shock. Patients with a cancer diagnosis face a much higher risk of infections after being immunosuppressed by chemotherapy, radiotherapy, or anti-inflammatory therapy, especially caused by non-pathogenic, Gram-negative, and multidrug-resistant pathogens. There is a notorious difference between the incidence and mortality rates related to sepsis in pediatric oncologic patients between developed and developing countries: they are much higher in developing countries, where investment for diagnosis and treatment resources, infrastructure, medical specialists, cancer-related control programs, and post-therapeutic care is insufficient. This situation not only limits but also reduces the life expectancy of treated pediatric oncologic patients, and demands higher costs from the healthcare systems. Therefore, efforts must aim to limit the progression of sepsis conditions, applying the most recommended therapeutic regimens as soon as the initial risk factors are clinically evident—or even before they are, as when taking advantage of machine learning prediction systems to analyze data. MDPI 2019-07-30 /pmc/articles/PMC6783913/ /pubmed/31366110 http://dx.doi.org/10.3390/antibiotics8030106 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Vázquez-López, Rosalino
Rivero Rojas, Omar
Ibarra Moreno, Andrea
Urrutia Favila, José Erik
Peña Barreto, Adan
Ortega Ortuño, Guadalupe Lizeth
Abello Vaamonde, Jorge Andrés
Aguilar Velazco, Ivanka Alejandra
Félix Castro, José Marcos
Solano-Gálvez, Sandra Georgina
Barrientos Fortes, Tomás
González-Barrios, Juan Antonio
Antibiotic-Resistant Septicemia in Pediatric Oncology Patients Associated with Post-Therapeutic Neutropenic Fever
title Antibiotic-Resistant Septicemia in Pediatric Oncology Patients Associated with Post-Therapeutic Neutropenic Fever
title_full Antibiotic-Resistant Septicemia in Pediatric Oncology Patients Associated with Post-Therapeutic Neutropenic Fever
title_fullStr Antibiotic-Resistant Septicemia in Pediatric Oncology Patients Associated with Post-Therapeutic Neutropenic Fever
title_full_unstemmed Antibiotic-Resistant Septicemia in Pediatric Oncology Patients Associated with Post-Therapeutic Neutropenic Fever
title_short Antibiotic-Resistant Septicemia in Pediatric Oncology Patients Associated with Post-Therapeutic Neutropenic Fever
title_sort antibiotic-resistant septicemia in pediatric oncology patients associated with post-therapeutic neutropenic fever
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783913/
https://www.ncbi.nlm.nih.gov/pubmed/31366110
http://dx.doi.org/10.3390/antibiotics8030106
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