Perspective on Adenoviruses: Epidemiology, Pathogenicity, and Gene Therapy

Human adenoviruses are large (150 MDa) doubled-stranded DNA viruses that cause respiratory infections. These viruses are particularly pathogenic in healthy and immune-compromised individuals, and currently, no adenovirus vaccine is available for the general public. The purpose of this review is to d...

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Autores principales: Crenshaw, Brennetta J., Jones, Leandra B., Bell, Courtnee’ R., Kumar, Sanjay, Matthews, Qiana L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784011/
https://www.ncbi.nlm.nih.gov/pubmed/31430920
http://dx.doi.org/10.3390/biomedicines7030061
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author Crenshaw, Brennetta J.
Jones, Leandra B.
Bell, Courtnee’ R.
Kumar, Sanjay
Matthews, Qiana L.
author_facet Crenshaw, Brennetta J.
Jones, Leandra B.
Bell, Courtnee’ R.
Kumar, Sanjay
Matthews, Qiana L.
author_sort Crenshaw, Brennetta J.
collection PubMed
description Human adenoviruses are large (150 MDa) doubled-stranded DNA viruses that cause respiratory infections. These viruses are particularly pathogenic in healthy and immune-compromised individuals, and currently, no adenovirus vaccine is available for the general public. The purpose of this review is to describe (i) the epidemiology and pathogenicity of human adenoviruses, (ii) the biological role of adenovirus vectors in gene therapy applications, and (iii) the potential role of exosomes in adenoviral infections.
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spelling pubmed-67840112019-10-16 Perspective on Adenoviruses: Epidemiology, Pathogenicity, and Gene Therapy Crenshaw, Brennetta J. Jones, Leandra B. Bell, Courtnee’ R. Kumar, Sanjay Matthews, Qiana L. Biomedicines Review Human adenoviruses are large (150 MDa) doubled-stranded DNA viruses that cause respiratory infections. These viruses are particularly pathogenic in healthy and immune-compromised individuals, and currently, no adenovirus vaccine is available for the general public. The purpose of this review is to describe (i) the epidemiology and pathogenicity of human adenoviruses, (ii) the biological role of adenovirus vectors in gene therapy applications, and (iii) the potential role of exosomes in adenoviral infections. MDPI 2019-08-19 /pmc/articles/PMC6784011/ /pubmed/31430920 http://dx.doi.org/10.3390/biomedicines7030061 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Crenshaw, Brennetta J.
Jones, Leandra B.
Bell, Courtnee’ R.
Kumar, Sanjay
Matthews, Qiana L.
Perspective on Adenoviruses: Epidemiology, Pathogenicity, and Gene Therapy
title Perspective on Adenoviruses: Epidemiology, Pathogenicity, and Gene Therapy
title_full Perspective on Adenoviruses: Epidemiology, Pathogenicity, and Gene Therapy
title_fullStr Perspective on Adenoviruses: Epidemiology, Pathogenicity, and Gene Therapy
title_full_unstemmed Perspective on Adenoviruses: Epidemiology, Pathogenicity, and Gene Therapy
title_short Perspective on Adenoviruses: Epidemiology, Pathogenicity, and Gene Therapy
title_sort perspective on adenoviruses: epidemiology, pathogenicity, and gene therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784011/
https://www.ncbi.nlm.nih.gov/pubmed/31430920
http://dx.doi.org/10.3390/biomedicines7030061
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