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Virus Shedding of Avian Influenza in Poultry: A Systematic Review and Meta-Analysis

Understanding virus shedding patterns of avian influenza virus (AIV) in poultry is important for understanding host-pathogen interactions and developing effective control strategies. Many AIV strains were studied in challenge experiments in poultry, but no study has combined data from those studies...

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Autores principales: Germeraad, Evelien A., Sanders, Pim, Hagenaars, Thomas J., de Jong, Mart C.M., Beerens, Nancy, Gonzales, Jose L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784017/
https://www.ncbi.nlm.nih.gov/pubmed/31480744
http://dx.doi.org/10.3390/v11090812
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author Germeraad, Evelien A.
Sanders, Pim
Hagenaars, Thomas J.
de Jong, Mart C.M.
Beerens, Nancy
Gonzales, Jose L.
author_facet Germeraad, Evelien A.
Sanders, Pim
Hagenaars, Thomas J.
de Jong, Mart C.M.
Beerens, Nancy
Gonzales, Jose L.
author_sort Germeraad, Evelien A.
collection PubMed
description Understanding virus shedding patterns of avian influenza virus (AIV) in poultry is important for understanding host-pathogen interactions and developing effective control strategies. Many AIV strains were studied in challenge experiments in poultry, but no study has combined data from those studies to identify general AIV shedding patterns. These systematic review and meta-analysis were performed to summarize qualitative and quantitative information on virus shedding levels and duration for different AIV strains in experimentally infected poultry species. Methods were designed based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Four electronic databases were used to collect literature. A total of 1155 abstract were screened, with 117 studies selected for the qualitative analysis and 71 studies for the meta-analysis. A large heterogeneity in experimental methods was observed and the quantitative analysis showed that experimental variables such as species, virus origin, age, inoculation route and dose, affect virus shedding (mean, peak and duration) for highly pathogenic AIV (HPAIV), low pathogenic AIV (LPAIV) or both. In conclusion, this study highlights the need to standardize experimental procedures, it provides a comprehensive summary of the shedding patterns of AIV strains by infected poultry and identifies the variables that influence the level and duration of AIV shedding.
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spelling pubmed-67840172019-10-16 Virus Shedding of Avian Influenza in Poultry: A Systematic Review and Meta-Analysis Germeraad, Evelien A. Sanders, Pim Hagenaars, Thomas J. de Jong, Mart C.M. Beerens, Nancy Gonzales, Jose L. Viruses Review Understanding virus shedding patterns of avian influenza virus (AIV) in poultry is important for understanding host-pathogen interactions and developing effective control strategies. Many AIV strains were studied in challenge experiments in poultry, but no study has combined data from those studies to identify general AIV shedding patterns. These systematic review and meta-analysis were performed to summarize qualitative and quantitative information on virus shedding levels and duration for different AIV strains in experimentally infected poultry species. Methods were designed based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Four electronic databases were used to collect literature. A total of 1155 abstract were screened, with 117 studies selected for the qualitative analysis and 71 studies for the meta-analysis. A large heterogeneity in experimental methods was observed and the quantitative analysis showed that experimental variables such as species, virus origin, age, inoculation route and dose, affect virus shedding (mean, peak and duration) for highly pathogenic AIV (HPAIV), low pathogenic AIV (LPAIV) or both. In conclusion, this study highlights the need to standardize experimental procedures, it provides a comprehensive summary of the shedding patterns of AIV strains by infected poultry and identifies the variables that influence the level and duration of AIV shedding. MDPI 2019-09-02 /pmc/articles/PMC6784017/ /pubmed/31480744 http://dx.doi.org/10.3390/v11090812 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Germeraad, Evelien A.
Sanders, Pim
Hagenaars, Thomas J.
de Jong, Mart C.M.
Beerens, Nancy
Gonzales, Jose L.
Virus Shedding of Avian Influenza in Poultry: A Systematic Review and Meta-Analysis
title Virus Shedding of Avian Influenza in Poultry: A Systematic Review and Meta-Analysis
title_full Virus Shedding of Avian Influenza in Poultry: A Systematic Review and Meta-Analysis
title_fullStr Virus Shedding of Avian Influenza in Poultry: A Systematic Review and Meta-Analysis
title_full_unstemmed Virus Shedding of Avian Influenza in Poultry: A Systematic Review and Meta-Analysis
title_short Virus Shedding of Avian Influenza in Poultry: A Systematic Review and Meta-Analysis
title_sort virus shedding of avian influenza in poultry: a systematic review and meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784017/
https://www.ncbi.nlm.nih.gov/pubmed/31480744
http://dx.doi.org/10.3390/v11090812
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