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A Mini-Review: Clinical Development and Potential of Aptamers for Thrombotic Events Treatment and Monitoring
The unique opportunity for aptamer uses in thrombotic events has sparked a considerable amount of research in the area. The short half-lives of unmodified aptamers in vivo remain one of the major challenges in therapeutic aptamers. Much of the incremental successful therapeutic aptamer stories were...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784064/ https://www.ncbi.nlm.nih.gov/pubmed/31357413 http://dx.doi.org/10.3390/biomedicines7030055 |
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author | Ponce, Alex T. Hong, Ka Lok |
author_facet | Ponce, Alex T. Hong, Ka Lok |
author_sort | Ponce, Alex T. |
collection | PubMed |
description | The unique opportunity for aptamer uses in thrombotic events has sparked a considerable amount of research in the area. The short half-lives of unmodified aptamers in vivo remain one of the major challenges in therapeutic aptamers. Much of the incremental successful therapeutic aptamer stories were due to modifications in the aptamer bases. This mini-review briefly summarizes the successes and challenges in the clinical development of aptamers for thrombotic events, and highlights some of the most recent developments in using aptamers for anticoagulation monitoring. |
format | Online Article Text |
id | pubmed-6784064 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-67840642019-10-16 A Mini-Review: Clinical Development and Potential of Aptamers for Thrombotic Events Treatment and Monitoring Ponce, Alex T. Hong, Ka Lok Biomedicines Review The unique opportunity for aptamer uses in thrombotic events has sparked a considerable amount of research in the area. The short half-lives of unmodified aptamers in vivo remain one of the major challenges in therapeutic aptamers. Much of the incremental successful therapeutic aptamer stories were due to modifications in the aptamer bases. This mini-review briefly summarizes the successes and challenges in the clinical development of aptamers for thrombotic events, and highlights some of the most recent developments in using aptamers for anticoagulation monitoring. MDPI 2019-07-26 /pmc/articles/PMC6784064/ /pubmed/31357413 http://dx.doi.org/10.3390/biomedicines7030055 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ponce, Alex T. Hong, Ka Lok A Mini-Review: Clinical Development and Potential of Aptamers for Thrombotic Events Treatment and Monitoring |
title | A Mini-Review: Clinical Development and Potential of Aptamers for Thrombotic Events Treatment and Monitoring |
title_full | A Mini-Review: Clinical Development and Potential of Aptamers for Thrombotic Events Treatment and Monitoring |
title_fullStr | A Mini-Review: Clinical Development and Potential of Aptamers for Thrombotic Events Treatment and Monitoring |
title_full_unstemmed | A Mini-Review: Clinical Development and Potential of Aptamers for Thrombotic Events Treatment and Monitoring |
title_short | A Mini-Review: Clinical Development and Potential of Aptamers for Thrombotic Events Treatment and Monitoring |
title_sort | mini-review: clinical development and potential of aptamers for thrombotic events treatment and monitoring |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784064/ https://www.ncbi.nlm.nih.gov/pubmed/31357413 http://dx.doi.org/10.3390/biomedicines7030055 |
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