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A Mini-Review: Clinical Development and Potential of Aptamers for Thrombotic Events Treatment and Monitoring

The unique opportunity for aptamer uses in thrombotic events has sparked a considerable amount of research in the area. The short half-lives of unmodified aptamers in vivo remain one of the major challenges in therapeutic aptamers. Much of the incremental successful therapeutic aptamer stories were...

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Detalles Bibliográficos
Autores principales: Ponce, Alex T., Hong, Ka Lok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784064/
https://www.ncbi.nlm.nih.gov/pubmed/31357413
http://dx.doi.org/10.3390/biomedicines7030055
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author Ponce, Alex T.
Hong, Ka Lok
author_facet Ponce, Alex T.
Hong, Ka Lok
author_sort Ponce, Alex T.
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description The unique opportunity for aptamer uses in thrombotic events has sparked a considerable amount of research in the area. The short half-lives of unmodified aptamers in vivo remain one of the major challenges in therapeutic aptamers. Much of the incremental successful therapeutic aptamer stories were due to modifications in the aptamer bases. This mini-review briefly summarizes the successes and challenges in the clinical development of aptamers for thrombotic events, and highlights some of the most recent developments in using aptamers for anticoagulation monitoring.
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spelling pubmed-67840642019-10-16 A Mini-Review: Clinical Development and Potential of Aptamers for Thrombotic Events Treatment and Monitoring Ponce, Alex T. Hong, Ka Lok Biomedicines Review The unique opportunity for aptamer uses in thrombotic events has sparked a considerable amount of research in the area. The short half-lives of unmodified aptamers in vivo remain one of the major challenges in therapeutic aptamers. Much of the incremental successful therapeutic aptamer stories were due to modifications in the aptamer bases. This mini-review briefly summarizes the successes and challenges in the clinical development of aptamers for thrombotic events, and highlights some of the most recent developments in using aptamers for anticoagulation monitoring. MDPI 2019-07-26 /pmc/articles/PMC6784064/ /pubmed/31357413 http://dx.doi.org/10.3390/biomedicines7030055 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ponce, Alex T.
Hong, Ka Lok
A Mini-Review: Clinical Development and Potential of Aptamers for Thrombotic Events Treatment and Monitoring
title A Mini-Review: Clinical Development and Potential of Aptamers for Thrombotic Events Treatment and Monitoring
title_full A Mini-Review: Clinical Development and Potential of Aptamers for Thrombotic Events Treatment and Monitoring
title_fullStr A Mini-Review: Clinical Development and Potential of Aptamers for Thrombotic Events Treatment and Monitoring
title_full_unstemmed A Mini-Review: Clinical Development and Potential of Aptamers for Thrombotic Events Treatment and Monitoring
title_short A Mini-Review: Clinical Development and Potential of Aptamers for Thrombotic Events Treatment and Monitoring
title_sort mini-review: clinical development and potential of aptamers for thrombotic events treatment and monitoring
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784064/
https://www.ncbi.nlm.nih.gov/pubmed/31357413
http://dx.doi.org/10.3390/biomedicines7030055
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