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Frequent Klebsiella pneumoniae Urinary Tract Infections in a Patient Treated with Ruxolitinib
Ruxolitinib is a targeted agent that inhibits Janus 2 Kinase and is approved for use in Polycythemia Vera and Primary Myelofibrosis. Its mechanism of action involves inhibition of cellular proliferation via the Janus kinase/signal transducer and activator of transcription proteins pathway. Ruxolitin...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784127/ https://www.ncbi.nlm.nih.gov/pubmed/31527456 http://dx.doi.org/10.3390/antibiotics8030150 |
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author | Hanna, Ramy M. Khalid, Maham El-Nour, Lama Abd Selamet, Umut |
author_facet | Hanna, Ramy M. Khalid, Maham El-Nour, Lama Abd Selamet, Umut |
author_sort | Hanna, Ramy M. |
collection | PubMed |
description | Ruxolitinib is a targeted agent that inhibits Janus 2 Kinase and is approved for use in Polycythemia Vera and Primary Myelofibrosis. Its mechanism of action involves inhibition of cellular proliferation via the Janus kinase/signal transducer and activator of transcription proteins pathway. Ruxolitinib has different immune modulating effects that result in functional immunosuppression, leading to an increased susceptibility to certain infections. Klebsiella pneumoniae infections, in particular, were common among the reported pathogens contracted by ruxolitinib users. We report a 75-year-old male patient who had recurrent K. pneumoniae urinary tract infections while on ruxolitinib for Polycythemia Vera. This case is reported to add to the literature describing an increased susceptibility of patients to this often-resistant bacteria and to raise awareness about the immune modulating effects of JAK inhibitors. |
format | Online Article Text |
id | pubmed-6784127 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-67841272019-10-16 Frequent Klebsiella pneumoniae Urinary Tract Infections in a Patient Treated with Ruxolitinib Hanna, Ramy M. Khalid, Maham El-Nour, Lama Abd Selamet, Umut Antibiotics (Basel) Case Report Ruxolitinib is a targeted agent that inhibits Janus 2 Kinase and is approved for use in Polycythemia Vera and Primary Myelofibrosis. Its mechanism of action involves inhibition of cellular proliferation via the Janus kinase/signal transducer and activator of transcription proteins pathway. Ruxolitinib has different immune modulating effects that result in functional immunosuppression, leading to an increased susceptibility to certain infections. Klebsiella pneumoniae infections, in particular, were common among the reported pathogens contracted by ruxolitinib users. We report a 75-year-old male patient who had recurrent K. pneumoniae urinary tract infections while on ruxolitinib for Polycythemia Vera. This case is reported to add to the literature describing an increased susceptibility of patients to this often-resistant bacteria and to raise awareness about the immune modulating effects of JAK inhibitors. MDPI 2019-09-16 /pmc/articles/PMC6784127/ /pubmed/31527456 http://dx.doi.org/10.3390/antibiotics8030150 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Hanna, Ramy M. Khalid, Maham El-Nour, Lama Abd Selamet, Umut Frequent Klebsiella pneumoniae Urinary Tract Infections in a Patient Treated with Ruxolitinib |
title | Frequent Klebsiella pneumoniae Urinary Tract Infections in a Patient Treated with Ruxolitinib |
title_full | Frequent Klebsiella pneumoniae Urinary Tract Infections in a Patient Treated with Ruxolitinib |
title_fullStr | Frequent Klebsiella pneumoniae Urinary Tract Infections in a Patient Treated with Ruxolitinib |
title_full_unstemmed | Frequent Klebsiella pneumoniae Urinary Tract Infections in a Patient Treated with Ruxolitinib |
title_short | Frequent Klebsiella pneumoniae Urinary Tract Infections in a Patient Treated with Ruxolitinib |
title_sort | frequent klebsiella pneumoniae urinary tract infections in a patient treated with ruxolitinib |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784127/ https://www.ncbi.nlm.nih.gov/pubmed/31527456 http://dx.doi.org/10.3390/antibiotics8030150 |
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