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Frequent Klebsiella pneumoniae Urinary Tract Infections in a Patient Treated with Ruxolitinib

Ruxolitinib is a targeted agent that inhibits Janus 2 Kinase and is approved for use in Polycythemia Vera and Primary Myelofibrosis. Its mechanism of action involves inhibition of cellular proliferation via the Janus kinase/signal transducer and activator of transcription proteins pathway. Ruxolitin...

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Autores principales: Hanna, Ramy M., Khalid, Maham, El-Nour, Lama Abd, Selamet, Umut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784127/
https://www.ncbi.nlm.nih.gov/pubmed/31527456
http://dx.doi.org/10.3390/antibiotics8030150
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author Hanna, Ramy M.
Khalid, Maham
El-Nour, Lama Abd
Selamet, Umut
author_facet Hanna, Ramy M.
Khalid, Maham
El-Nour, Lama Abd
Selamet, Umut
author_sort Hanna, Ramy M.
collection PubMed
description Ruxolitinib is a targeted agent that inhibits Janus 2 Kinase and is approved for use in Polycythemia Vera and Primary Myelofibrosis. Its mechanism of action involves inhibition of cellular proliferation via the Janus kinase/signal transducer and activator of transcription proteins pathway. Ruxolitinib has different immune modulating effects that result in functional immunosuppression, leading to an increased susceptibility to certain infections. Klebsiella pneumoniae infections, in particular, were common among the reported pathogens contracted by ruxolitinib users. We report a 75-year-old male patient who had recurrent K. pneumoniae urinary tract infections while on ruxolitinib for Polycythemia Vera. This case is reported to add to the literature describing an increased susceptibility of patients to this often-resistant bacteria and to raise awareness about the immune modulating effects of JAK inhibitors.
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spelling pubmed-67841272019-10-16 Frequent Klebsiella pneumoniae Urinary Tract Infections in a Patient Treated with Ruxolitinib Hanna, Ramy M. Khalid, Maham El-Nour, Lama Abd Selamet, Umut Antibiotics (Basel) Case Report Ruxolitinib is a targeted agent that inhibits Janus 2 Kinase and is approved for use in Polycythemia Vera and Primary Myelofibrosis. Its mechanism of action involves inhibition of cellular proliferation via the Janus kinase/signal transducer and activator of transcription proteins pathway. Ruxolitinib has different immune modulating effects that result in functional immunosuppression, leading to an increased susceptibility to certain infections. Klebsiella pneumoniae infections, in particular, were common among the reported pathogens contracted by ruxolitinib users. We report a 75-year-old male patient who had recurrent K. pneumoniae urinary tract infections while on ruxolitinib for Polycythemia Vera. This case is reported to add to the literature describing an increased susceptibility of patients to this often-resistant bacteria and to raise awareness about the immune modulating effects of JAK inhibitors. MDPI 2019-09-16 /pmc/articles/PMC6784127/ /pubmed/31527456 http://dx.doi.org/10.3390/antibiotics8030150 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Hanna, Ramy M.
Khalid, Maham
El-Nour, Lama Abd
Selamet, Umut
Frequent Klebsiella pneumoniae Urinary Tract Infections in a Patient Treated with Ruxolitinib
title Frequent Klebsiella pneumoniae Urinary Tract Infections in a Patient Treated with Ruxolitinib
title_full Frequent Klebsiella pneumoniae Urinary Tract Infections in a Patient Treated with Ruxolitinib
title_fullStr Frequent Klebsiella pneumoniae Urinary Tract Infections in a Patient Treated with Ruxolitinib
title_full_unstemmed Frequent Klebsiella pneumoniae Urinary Tract Infections in a Patient Treated with Ruxolitinib
title_short Frequent Klebsiella pneumoniae Urinary Tract Infections in a Patient Treated with Ruxolitinib
title_sort frequent klebsiella pneumoniae urinary tract infections in a patient treated with ruxolitinib
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784127/
https://www.ncbi.nlm.nih.gov/pubmed/31527456
http://dx.doi.org/10.3390/antibiotics8030150
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