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Finite Element Driven Design Domain Identification of a Beating Left Ventricular Simulator

Almost ten percent of the American population have heart diseases. Since the number of available heart donors is not promising, left ventricular assist devices are implemented as bridge therapies. Development of the assist devices benefits from both in-vivo animal and in-vitro mock circulation studi...

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Autores principales: Gulbulak, Utku, Ertas, Atila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784146/
https://www.ncbi.nlm.nih.gov/pubmed/31540196
http://dx.doi.org/10.3390/bioengineering6030083
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author Gulbulak, Utku
Ertas, Atila
author_facet Gulbulak, Utku
Ertas, Atila
author_sort Gulbulak, Utku
collection PubMed
description Almost ten percent of the American population have heart diseases. Since the number of available heart donors is not promising, left ventricular assist devices are implemented as bridge therapies. Development of the assist devices benefits from both in-vivo animal and in-vitro mock circulation studies. Representation of the heart is a crucial part of the mock circulation setups. Recently, a beating left ventricular simulator with latex rubber and helically oriented McKibben actuators has been proposed. The simulator was able to mimic heart wall motion, however, flow rate was reported to be limited to 2 liters per minute. This study offers a finite element driven design domain identification to identify the combination of wall thickness, number of actuators, and the orientation angle that results in better deformation. A nonlinear finite element model of the simulator was developed and validated. Design domain was constructed with 150 finite element models, each with varying wall thickness and number of actuators with varying orientation angles. Results showed that the combination of 4 mm wall thickness and 8 actuators with 90 degrees orientation performed best in the design domain.
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spelling pubmed-67841462019-10-16 Finite Element Driven Design Domain Identification of a Beating Left Ventricular Simulator Gulbulak, Utku Ertas, Atila Bioengineering (Basel) Article Almost ten percent of the American population have heart diseases. Since the number of available heart donors is not promising, left ventricular assist devices are implemented as bridge therapies. Development of the assist devices benefits from both in-vivo animal and in-vitro mock circulation studies. Representation of the heart is a crucial part of the mock circulation setups. Recently, a beating left ventricular simulator with latex rubber and helically oriented McKibben actuators has been proposed. The simulator was able to mimic heart wall motion, however, flow rate was reported to be limited to 2 liters per minute. This study offers a finite element driven design domain identification to identify the combination of wall thickness, number of actuators, and the orientation angle that results in better deformation. A nonlinear finite element model of the simulator was developed and validated. Design domain was constructed with 150 finite element models, each with varying wall thickness and number of actuators with varying orientation angles. Results showed that the combination of 4 mm wall thickness and 8 actuators with 90 degrees orientation performed best in the design domain. MDPI 2019-09-13 /pmc/articles/PMC6784146/ /pubmed/31540196 http://dx.doi.org/10.3390/bioengineering6030083 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gulbulak, Utku
Ertas, Atila
Finite Element Driven Design Domain Identification of a Beating Left Ventricular Simulator
title Finite Element Driven Design Domain Identification of a Beating Left Ventricular Simulator
title_full Finite Element Driven Design Domain Identification of a Beating Left Ventricular Simulator
title_fullStr Finite Element Driven Design Domain Identification of a Beating Left Ventricular Simulator
title_full_unstemmed Finite Element Driven Design Domain Identification of a Beating Left Ventricular Simulator
title_short Finite Element Driven Design Domain Identification of a Beating Left Ventricular Simulator
title_sort finite element driven design domain identification of a beating left ventricular simulator
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784146/
https://www.ncbi.nlm.nih.gov/pubmed/31540196
http://dx.doi.org/10.3390/bioengineering6030083
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