Pulmonary Involvement during the Ebola Virus Disease

Filoviruses have become a worldwide public health concern, especially during the 2013–2016 Western Africa Ebola virus disease (EVD) outbreak—the largest outbreak, both by number of cases and geographical extension, recorded so far in medical history. EVD is associated with pathologies in several org...

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Autores principales: Lalle, Eleonora, Biava, Mirella, Nicastri, Emanuele, Colavita, Francesca, Di Caro, Antonino, Vairo, Francesco, Lanini, Simone, Castilletti, Concetta, Langer, Martin, Zumla, Alimuddin, Kobinger, Gary, Capobianchi, Maria R., Ippolito, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784166/
https://www.ncbi.nlm.nih.gov/pubmed/31450596
http://dx.doi.org/10.3390/v11090780
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author Lalle, Eleonora
Biava, Mirella
Nicastri, Emanuele
Colavita, Francesca
Di Caro, Antonino
Vairo, Francesco
Lanini, Simone
Castilletti, Concetta
Langer, Martin
Zumla, Alimuddin
Kobinger, Gary
Capobianchi, Maria R.
Ippolito, Giuseppe
author_facet Lalle, Eleonora
Biava, Mirella
Nicastri, Emanuele
Colavita, Francesca
Di Caro, Antonino
Vairo, Francesco
Lanini, Simone
Castilletti, Concetta
Langer, Martin
Zumla, Alimuddin
Kobinger, Gary
Capobianchi, Maria R.
Ippolito, Giuseppe
author_sort Lalle, Eleonora
collection PubMed
description Filoviruses have become a worldwide public health concern, especially during the 2013–2016 Western Africa Ebola virus disease (EVD) outbreak—the largest outbreak, both by number of cases and geographical extension, recorded so far in medical history. EVD is associated with pathologies in several organs, including the liver, kidney, and lung. During the 2013–2016 Western Africa outbreak, Ebola virus (EBOV) was detected in the lung of infected patients suggesting a role in lung pathogenesis. However, little is known about lung pathogenesis and the controversial issue of aerosol transmission in EVD. This review highlights the pulmonary involvement in EVD, with a special focus on the new data emerging from the 2013–2016 Ebola outbreak.
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spelling pubmed-67841662019-10-16 Pulmonary Involvement during the Ebola Virus Disease Lalle, Eleonora Biava, Mirella Nicastri, Emanuele Colavita, Francesca Di Caro, Antonino Vairo, Francesco Lanini, Simone Castilletti, Concetta Langer, Martin Zumla, Alimuddin Kobinger, Gary Capobianchi, Maria R. Ippolito, Giuseppe Viruses Review Filoviruses have become a worldwide public health concern, especially during the 2013–2016 Western Africa Ebola virus disease (EVD) outbreak—the largest outbreak, both by number of cases and geographical extension, recorded so far in medical history. EVD is associated with pathologies in several organs, including the liver, kidney, and lung. During the 2013–2016 Western Africa outbreak, Ebola virus (EBOV) was detected in the lung of infected patients suggesting a role in lung pathogenesis. However, little is known about lung pathogenesis and the controversial issue of aerosol transmission in EVD. This review highlights the pulmonary involvement in EVD, with a special focus on the new data emerging from the 2013–2016 Ebola outbreak. MDPI 2019-08-24 /pmc/articles/PMC6784166/ /pubmed/31450596 http://dx.doi.org/10.3390/v11090780 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lalle, Eleonora
Biava, Mirella
Nicastri, Emanuele
Colavita, Francesca
Di Caro, Antonino
Vairo, Francesco
Lanini, Simone
Castilletti, Concetta
Langer, Martin
Zumla, Alimuddin
Kobinger, Gary
Capobianchi, Maria R.
Ippolito, Giuseppe
Pulmonary Involvement during the Ebola Virus Disease
title Pulmonary Involvement during the Ebola Virus Disease
title_full Pulmonary Involvement during the Ebola Virus Disease
title_fullStr Pulmonary Involvement during the Ebola Virus Disease
title_full_unstemmed Pulmonary Involvement during the Ebola Virus Disease
title_short Pulmonary Involvement during the Ebola Virus Disease
title_sort pulmonary involvement during the ebola virus disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784166/
https://www.ncbi.nlm.nih.gov/pubmed/31450596
http://dx.doi.org/10.3390/v11090780
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