Preparation and Characterization of Perforated SERS Active Array for Particle Trapping and Sensitive Molecular Analysis

A gold-coated array of flow-through inverse pyramids applicable as substrate for entrapment and immobilization of micro-objects and for surface enhanced Raman spectroscopic measurements was fabricated using bulk micromachining techniques from silicon. Surface morphology, optical reflectance, immobil...

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Detalles Bibliográficos
Autores principales: Rigó, István, Veres, Miklós, Váczi, Tamás, Holczer, Eszter, Hakkel, Orsolya, Deák, András, Fürjes, Péter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784355/
https://www.ncbi.nlm.nih.gov/pubmed/31349554
http://dx.doi.org/10.3390/bios9030093
Descripción
Sumario:A gold-coated array of flow-through inverse pyramids applicable as substrate for entrapment and immobilization of micro-objects and for surface enhanced Raman spectroscopic measurements was fabricated using bulk micromachining techniques from silicon. Surface morphology, optical reflectance, immobilization properties, and surface enhanced Raman amplification of the array were modelled and characterized. It was found that the special perforated periodic 3D structure can be used for parallel particle and cell trapping and highly sensitive molecular analysis of the immobilized objects.

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