Preparation and Characterization of Perforated SERS Active Array for Particle Trapping and Sensitive Molecular Analysis

A gold-coated array of flow-through inverse pyramids applicable as substrate for entrapment and immobilization of micro-objects and for surface enhanced Raman spectroscopic measurements was fabricated using bulk micromachining techniques from silicon. Surface morphology, optical reflectance, immobil...

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Autores principales: Rigó, István, Veres, Miklós, Váczi, Tamás, Holczer, Eszter, Hakkel, Orsolya, Deák, András, Fürjes, Péter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784355/
https://www.ncbi.nlm.nih.gov/pubmed/31349554
http://dx.doi.org/10.3390/bios9030093
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author Rigó, István
Veres, Miklós
Váczi, Tamás
Holczer, Eszter
Hakkel, Orsolya
Deák, András
Fürjes, Péter
author_facet Rigó, István
Veres, Miklós
Váczi, Tamás
Holczer, Eszter
Hakkel, Orsolya
Deák, András
Fürjes, Péter
author_sort Rigó, István
collection PubMed
description A gold-coated array of flow-through inverse pyramids applicable as substrate for entrapment and immobilization of micro-objects and for surface enhanced Raman spectroscopic measurements was fabricated using bulk micromachining techniques from silicon. Surface morphology, optical reflectance, immobilization properties, and surface enhanced Raman amplification of the array were modelled and characterized. It was found that the special perforated periodic 3D structure can be used for parallel particle and cell trapping and highly sensitive molecular analysis of the immobilized objects.
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spelling pubmed-67843552019-10-16 Preparation and Characterization of Perforated SERS Active Array for Particle Trapping and Sensitive Molecular Analysis Rigó, István Veres, Miklós Váczi, Tamás Holczer, Eszter Hakkel, Orsolya Deák, András Fürjes, Péter Biosensors (Basel) Article A gold-coated array of flow-through inverse pyramids applicable as substrate for entrapment and immobilization of micro-objects and for surface enhanced Raman spectroscopic measurements was fabricated using bulk micromachining techniques from silicon. Surface morphology, optical reflectance, immobilization properties, and surface enhanced Raman amplification of the array were modelled and characterized. It was found that the special perforated periodic 3D structure can be used for parallel particle and cell trapping and highly sensitive molecular analysis of the immobilized objects. MDPI 2019-07-25 /pmc/articles/PMC6784355/ /pubmed/31349554 http://dx.doi.org/10.3390/bios9030093 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rigó, István
Veres, Miklós
Váczi, Tamás
Holczer, Eszter
Hakkel, Orsolya
Deák, András
Fürjes, Péter
Preparation and Characterization of Perforated SERS Active Array for Particle Trapping and Sensitive Molecular Analysis
title Preparation and Characterization of Perforated SERS Active Array for Particle Trapping and Sensitive Molecular Analysis
title_full Preparation and Characterization of Perforated SERS Active Array for Particle Trapping and Sensitive Molecular Analysis
title_fullStr Preparation and Characterization of Perforated SERS Active Array for Particle Trapping and Sensitive Molecular Analysis
title_full_unstemmed Preparation and Characterization of Perforated SERS Active Array for Particle Trapping and Sensitive Molecular Analysis
title_short Preparation and Characterization of Perforated SERS Active Array for Particle Trapping and Sensitive Molecular Analysis
title_sort preparation and characterization of perforated sers active array for particle trapping and sensitive molecular analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784355/
https://www.ncbi.nlm.nih.gov/pubmed/31349554
http://dx.doi.org/10.3390/bios9030093
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