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Dielectrophoresis Multipath Focusing of Microparticles through Perforated Electrodes in Microfluidic Channels

This paper presents focusing of microparticles in multiple paths within the direction of the flow using dielectrophoresis. The focusing of microparticles is realized through partially perforated electrodes within the microchannel. A continuous electrode on the top surface of the microchannel is cons...

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Autores principales: Alazzam, Anas, Al-Khaleel, Mohammad, Riahi, Mohamed Kamel, Mathew, Bobby, Gawanmeh, Amjad, Nerguizian, Vahé
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784380/
https://www.ncbi.nlm.nih.gov/pubmed/31394810
http://dx.doi.org/10.3390/bios9030099
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author Alazzam, Anas
Al-Khaleel, Mohammad
Riahi, Mohamed Kamel
Mathew, Bobby
Gawanmeh, Amjad
Nerguizian, Vahé
author_facet Alazzam, Anas
Al-Khaleel, Mohammad
Riahi, Mohamed Kamel
Mathew, Bobby
Gawanmeh, Amjad
Nerguizian, Vahé
author_sort Alazzam, Anas
collection PubMed
description This paper presents focusing of microparticles in multiple paths within the direction of the flow using dielectrophoresis. The focusing of microparticles is realized through partially perforated electrodes within the microchannel. A continuous electrode on the top surface of the microchannel is considered, while the bottom side is made of a circular meshed perforated electrode. For the mathematical model of this microfluidic channel, inertia, buoyancy, drag and dielectrophoretic forces are brought up in the motion equation of the microparticles. The dielectrophoretic force is accounted for through a finite element discretization taking into account the perforated 3D geometry within the microchannel. An ordinary differential equation is solved to track the trajectories of the microparticles. For the case of continuous electrodes using the same mathematical model, the numerical simulation shows a very good agreement with the experiments, and this confirms the validation of focusing of microparticles within the proposed perforated electrode microchannel. Microparticles of silicon dioxide and polystyrene are used for this analysis. Their initial positions and radius, the Reynolds number, and the radius of the pore in perforated electrodes mainly conduct microparticles trajectories. Moreover, the radius of the pore of perforated electrode is the dominant factor in the steady state levitation height.
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spelling pubmed-67843802019-10-16 Dielectrophoresis Multipath Focusing of Microparticles through Perforated Electrodes in Microfluidic Channels Alazzam, Anas Al-Khaleel, Mohammad Riahi, Mohamed Kamel Mathew, Bobby Gawanmeh, Amjad Nerguizian, Vahé Biosensors (Basel) Article This paper presents focusing of microparticles in multiple paths within the direction of the flow using dielectrophoresis. The focusing of microparticles is realized through partially perforated electrodes within the microchannel. A continuous electrode on the top surface of the microchannel is considered, while the bottom side is made of a circular meshed perforated electrode. For the mathematical model of this microfluidic channel, inertia, buoyancy, drag and dielectrophoretic forces are brought up in the motion equation of the microparticles. The dielectrophoretic force is accounted for through a finite element discretization taking into account the perforated 3D geometry within the microchannel. An ordinary differential equation is solved to track the trajectories of the microparticles. For the case of continuous electrodes using the same mathematical model, the numerical simulation shows a very good agreement with the experiments, and this confirms the validation of focusing of microparticles within the proposed perforated electrode microchannel. Microparticles of silicon dioxide and polystyrene are used for this analysis. Their initial positions and radius, the Reynolds number, and the radius of the pore in perforated electrodes mainly conduct microparticles trajectories. Moreover, the radius of the pore of perforated electrode is the dominant factor in the steady state levitation height. MDPI 2019-08-07 /pmc/articles/PMC6784380/ /pubmed/31394810 http://dx.doi.org/10.3390/bios9030099 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Alazzam, Anas
Al-Khaleel, Mohammad
Riahi, Mohamed Kamel
Mathew, Bobby
Gawanmeh, Amjad
Nerguizian, Vahé
Dielectrophoresis Multipath Focusing of Microparticles through Perforated Electrodes in Microfluidic Channels
title Dielectrophoresis Multipath Focusing of Microparticles through Perforated Electrodes in Microfluidic Channels
title_full Dielectrophoresis Multipath Focusing of Microparticles through Perforated Electrodes in Microfluidic Channels
title_fullStr Dielectrophoresis Multipath Focusing of Microparticles through Perforated Electrodes in Microfluidic Channels
title_full_unstemmed Dielectrophoresis Multipath Focusing of Microparticles through Perforated Electrodes in Microfluidic Channels
title_short Dielectrophoresis Multipath Focusing of Microparticles through Perforated Electrodes in Microfluidic Channels
title_sort dielectrophoresis multipath focusing of microparticles through perforated electrodes in microfluidic channels
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784380/
https://www.ncbi.nlm.nih.gov/pubmed/31394810
http://dx.doi.org/10.3390/bios9030099
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