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Use of an Insulation Layer on the Connection Tracks of a Biosensor with Coplanar Electrodes to Increase the Normalized Impedance Variation

New technologies, such as biosensors and lab-on-a-chip, are reducing time consumption and costs for the detection and characterization of biological cells. One challenge is to detect and characterize cells and bacteria one by one or at a very low concentration. In this case, measurements have very l...

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Autores principales: Alves de Araujo, Arthur Luiz, Claudel, Julien, Kourtiche, Djilali, Nadi, Mustapha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784382/
https://www.ncbi.nlm.nih.gov/pubmed/31527557
http://dx.doi.org/10.3390/bios9030108
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author Alves de Araujo, Arthur Luiz
Claudel, Julien
Kourtiche, Djilali
Nadi, Mustapha
author_facet Alves de Araujo, Arthur Luiz
Claudel, Julien
Kourtiche, Djilali
Nadi, Mustapha
author_sort Alves de Araujo, Arthur Luiz
collection PubMed
description New technologies, such as biosensors and lab-on-a-chip, are reducing time consumption and costs for the detection and characterization of biological cells. One challenge is to detect and characterize cells and bacteria one by one or at a very low concentration. In this case, measurements have very low variations that can be difficult to detect. In this article, the use of an insulation layer on the connection tracks of a biosensor with coplanar electrodes is proposed to improve a biosensor previously developed. The impedance spectroscopy technique was used to analyze the influence of the insulation layer on the cutoff frequencies and on the normalized impedance variation. This solution does not induce changes in the cutoff frequencies, though it permits improving the normalized impedance variations, compared to the same biosensor without the insulation layer.
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spelling pubmed-67843822019-10-16 Use of an Insulation Layer on the Connection Tracks of a Biosensor with Coplanar Electrodes to Increase the Normalized Impedance Variation Alves de Araujo, Arthur Luiz Claudel, Julien Kourtiche, Djilali Nadi, Mustapha Biosensors (Basel) Article New technologies, such as biosensors and lab-on-a-chip, are reducing time consumption and costs for the detection and characterization of biological cells. One challenge is to detect and characterize cells and bacteria one by one or at a very low concentration. In this case, measurements have very low variations that can be difficult to detect. In this article, the use of an insulation layer on the connection tracks of a biosensor with coplanar electrodes is proposed to improve a biosensor previously developed. The impedance spectroscopy technique was used to analyze the influence of the insulation layer on the cutoff frequencies and on the normalized impedance variation. This solution does not induce changes in the cutoff frequencies, though it permits improving the normalized impedance variations, compared to the same biosensor without the insulation layer. MDPI 2019-09-16 /pmc/articles/PMC6784382/ /pubmed/31527557 http://dx.doi.org/10.3390/bios9030108 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Alves de Araujo, Arthur Luiz
Claudel, Julien
Kourtiche, Djilali
Nadi, Mustapha
Use of an Insulation Layer on the Connection Tracks of a Biosensor with Coplanar Electrodes to Increase the Normalized Impedance Variation
title Use of an Insulation Layer on the Connection Tracks of a Biosensor with Coplanar Electrodes to Increase the Normalized Impedance Variation
title_full Use of an Insulation Layer on the Connection Tracks of a Biosensor with Coplanar Electrodes to Increase the Normalized Impedance Variation
title_fullStr Use of an Insulation Layer on the Connection Tracks of a Biosensor with Coplanar Electrodes to Increase the Normalized Impedance Variation
title_full_unstemmed Use of an Insulation Layer on the Connection Tracks of a Biosensor with Coplanar Electrodes to Increase the Normalized Impedance Variation
title_short Use of an Insulation Layer on the Connection Tracks of a Biosensor with Coplanar Electrodes to Increase the Normalized Impedance Variation
title_sort use of an insulation layer on the connection tracks of a biosensor with coplanar electrodes to increase the normalized impedance variation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784382/
https://www.ncbi.nlm.nih.gov/pubmed/31527557
http://dx.doi.org/10.3390/bios9030108
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