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Use of an Insulation Layer on the Connection Tracks of a Biosensor with Coplanar Electrodes to Increase the Normalized Impedance Variation
New technologies, such as biosensors and lab-on-a-chip, are reducing time consumption and costs for the detection and characterization of biological cells. One challenge is to detect and characterize cells and bacteria one by one or at a very low concentration. In this case, measurements have very l...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784382/ https://www.ncbi.nlm.nih.gov/pubmed/31527557 http://dx.doi.org/10.3390/bios9030108 |
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author | Alves de Araujo, Arthur Luiz Claudel, Julien Kourtiche, Djilali Nadi, Mustapha |
author_facet | Alves de Araujo, Arthur Luiz Claudel, Julien Kourtiche, Djilali Nadi, Mustapha |
author_sort | Alves de Araujo, Arthur Luiz |
collection | PubMed |
description | New technologies, such as biosensors and lab-on-a-chip, are reducing time consumption and costs for the detection and characterization of biological cells. One challenge is to detect and characterize cells and bacteria one by one or at a very low concentration. In this case, measurements have very low variations that can be difficult to detect. In this article, the use of an insulation layer on the connection tracks of a biosensor with coplanar electrodes is proposed to improve a biosensor previously developed. The impedance spectroscopy technique was used to analyze the influence of the insulation layer on the cutoff frequencies and on the normalized impedance variation. This solution does not induce changes in the cutoff frequencies, though it permits improving the normalized impedance variations, compared to the same biosensor without the insulation layer. |
format | Online Article Text |
id | pubmed-6784382 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-67843822019-10-16 Use of an Insulation Layer on the Connection Tracks of a Biosensor with Coplanar Electrodes to Increase the Normalized Impedance Variation Alves de Araujo, Arthur Luiz Claudel, Julien Kourtiche, Djilali Nadi, Mustapha Biosensors (Basel) Article New technologies, such as biosensors and lab-on-a-chip, are reducing time consumption and costs for the detection and characterization of biological cells. One challenge is to detect and characterize cells and bacteria one by one or at a very low concentration. In this case, measurements have very low variations that can be difficult to detect. In this article, the use of an insulation layer on the connection tracks of a biosensor with coplanar electrodes is proposed to improve a biosensor previously developed. The impedance spectroscopy technique was used to analyze the influence of the insulation layer on the cutoff frequencies and on the normalized impedance variation. This solution does not induce changes in the cutoff frequencies, though it permits improving the normalized impedance variations, compared to the same biosensor without the insulation layer. MDPI 2019-09-16 /pmc/articles/PMC6784382/ /pubmed/31527557 http://dx.doi.org/10.3390/bios9030108 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Alves de Araujo, Arthur Luiz Claudel, Julien Kourtiche, Djilali Nadi, Mustapha Use of an Insulation Layer on the Connection Tracks of a Biosensor with Coplanar Electrodes to Increase the Normalized Impedance Variation |
title | Use of an Insulation Layer on the Connection Tracks of a Biosensor with Coplanar Electrodes to Increase the Normalized Impedance Variation |
title_full | Use of an Insulation Layer on the Connection Tracks of a Biosensor with Coplanar Electrodes to Increase the Normalized Impedance Variation |
title_fullStr | Use of an Insulation Layer on the Connection Tracks of a Biosensor with Coplanar Electrodes to Increase the Normalized Impedance Variation |
title_full_unstemmed | Use of an Insulation Layer on the Connection Tracks of a Biosensor with Coplanar Electrodes to Increase the Normalized Impedance Variation |
title_short | Use of an Insulation Layer on the Connection Tracks of a Biosensor with Coplanar Electrodes to Increase the Normalized Impedance Variation |
title_sort | use of an insulation layer on the connection tracks of a biosensor with coplanar electrodes to increase the normalized impedance variation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784382/ https://www.ncbi.nlm.nih.gov/pubmed/31527557 http://dx.doi.org/10.3390/bios9030108 |
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