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Pulmonary dysfunction among adolescents and adults with sickle cell disease in Nigeria: Implications for monitoring

BACKGROUND: Pulmonary complications of sickle cell disease (SCD) contribute to excess morbidity and mortality. The burden of pulmonary dysfunction among Nigerians with SCD has not been well elucidated. OBJECTIVES: The objectives of this study are to describe the frequency and pattern of spirometry a...

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Autores principales: Ozoh, Obianuju B., Kalejaiye, Olufunto O., Eromesele, Ojiebun E., Adelabu, Yusuf A., Dede, Sandra K., Ogunlesi, Folasade O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784438/
https://www.ncbi.nlm.nih.gov/pubmed/31620211
http://dx.doi.org/10.4103/atm.ATM_58_19
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author Ozoh, Obianuju B.
Kalejaiye, Olufunto O.
Eromesele, Ojiebun E.
Adelabu, Yusuf A.
Dede, Sandra K.
Ogunlesi, Folasade O.
author_facet Ozoh, Obianuju B.
Kalejaiye, Olufunto O.
Eromesele, Ojiebun E.
Adelabu, Yusuf A.
Dede, Sandra K.
Ogunlesi, Folasade O.
author_sort Ozoh, Obianuju B.
collection PubMed
description BACKGROUND: Pulmonary complications of sickle cell disease (SCD) contribute to excess morbidity and mortality. The burden of pulmonary dysfunction among Nigerians with SCD has not been well elucidated. OBJECTIVES: The objectives of this study are to describe the frequency and pattern of spirometry abnormalities in SCD and to explore the association between pulmonary dysfunction and selected parameters. METHODS: A cross-sectional study among adolescents and adults with SCD attending a University Teaching Hospital and healthy age- and gender-matched controls. Respiratory symptoms, oxygen saturation, spirometry, complete blood counts, and fetal hemoglobin (Hb) were measured. RESULTS: A total of 245 participants with SCD and 216 controls were included in the study. Frequency of respiratory symptoms was similar between the two groups. The median forced expiratory volume 1 (FEV1), forced vital capacity (FVC), and the FEV1/FVC were significantly lower in SCD as compared to controls (P = 0.000 in all instances). The frequency of abnormal pulmonary patterns was higher in SCD as compared to controls with abnormal spirometry pattern in 174 (71%) and 68 (31.5%) of participants with SCD and controls, respectively (P = 0.000). The suggestive of restrictive pattern was predominant (48% vs. 23%), but obstructive (11.8% vs. 7.4%) and mixed patterns (11% vs. 0.9%) were also found among SCD versus controls. Hb concentration was positively associated with FEV1 and FVC, whereas white cell count and age were negatively associated with FVC and FEV1, respectively. CONCLUSION: There is a high burden of pulmonary dysfunction in SCD among Nigerians which may be related to the severity of disease. There is a need for further research to explore the effectiveness of potential interventions so as to harness the benefits from monitoring and early detection.
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spelling pubmed-67844382019-10-16 Pulmonary dysfunction among adolescents and adults with sickle cell disease in Nigeria: Implications for monitoring Ozoh, Obianuju B. Kalejaiye, Olufunto O. Eromesele, Ojiebun E. Adelabu, Yusuf A. Dede, Sandra K. Ogunlesi, Folasade O. Ann Thorac Med Original Article BACKGROUND: Pulmonary complications of sickle cell disease (SCD) contribute to excess morbidity and mortality. The burden of pulmonary dysfunction among Nigerians with SCD has not been well elucidated. OBJECTIVES: The objectives of this study are to describe the frequency and pattern of spirometry abnormalities in SCD and to explore the association between pulmonary dysfunction and selected parameters. METHODS: A cross-sectional study among adolescents and adults with SCD attending a University Teaching Hospital and healthy age- and gender-matched controls. Respiratory symptoms, oxygen saturation, spirometry, complete blood counts, and fetal hemoglobin (Hb) were measured. RESULTS: A total of 245 participants with SCD and 216 controls were included in the study. Frequency of respiratory symptoms was similar between the two groups. The median forced expiratory volume 1 (FEV1), forced vital capacity (FVC), and the FEV1/FVC were significantly lower in SCD as compared to controls (P = 0.000 in all instances). The frequency of abnormal pulmonary patterns was higher in SCD as compared to controls with abnormal spirometry pattern in 174 (71%) and 68 (31.5%) of participants with SCD and controls, respectively (P = 0.000). The suggestive of restrictive pattern was predominant (48% vs. 23%), but obstructive (11.8% vs. 7.4%) and mixed patterns (11% vs. 0.9%) were also found among SCD versus controls. Hb concentration was positively associated with FEV1 and FVC, whereas white cell count and age were negatively associated with FVC and FEV1, respectively. CONCLUSION: There is a high burden of pulmonary dysfunction in SCD among Nigerians which may be related to the severity of disease. There is a need for further research to explore the effectiveness of potential interventions so as to harness the benefits from monitoring and early detection. Wolters Kluwer - Medknow 2019 /pmc/articles/PMC6784438/ /pubmed/31620211 http://dx.doi.org/10.4103/atm.ATM_58_19 Text en Copyright: © 2019 Annals of Thoracic Medicine http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Ozoh, Obianuju B.
Kalejaiye, Olufunto O.
Eromesele, Ojiebun E.
Adelabu, Yusuf A.
Dede, Sandra K.
Ogunlesi, Folasade O.
Pulmonary dysfunction among adolescents and adults with sickle cell disease in Nigeria: Implications for monitoring
title Pulmonary dysfunction among adolescents and adults with sickle cell disease in Nigeria: Implications for monitoring
title_full Pulmonary dysfunction among adolescents and adults with sickle cell disease in Nigeria: Implications for monitoring
title_fullStr Pulmonary dysfunction among adolescents and adults with sickle cell disease in Nigeria: Implications for monitoring
title_full_unstemmed Pulmonary dysfunction among adolescents and adults with sickle cell disease in Nigeria: Implications for monitoring
title_short Pulmonary dysfunction among adolescents and adults with sickle cell disease in Nigeria: Implications for monitoring
title_sort pulmonary dysfunction among adolescents and adults with sickle cell disease in nigeria: implications for monitoring
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784438/
https://www.ncbi.nlm.nih.gov/pubmed/31620211
http://dx.doi.org/10.4103/atm.ATM_58_19
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