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Defective base excision repair in the response to DNA damaging agents in triple negative breast cancer

DNA repair defects have been increasingly focused on as therapeutic targets. In hormone-positive breast cancer, XRCC1-deficient tumors have been identified and proposed as targets for combination therapies that damage DNA and inhibit DNA repair pathways. XRCC1 is a scaffold protein that functions in...

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Detalles Bibliográficos
Autores principales:	Lee, Kevin J., Piett, Cortt G., Andrews, Joel F., Mann, Elise, Nagel, Zachary D., Gassman, Natalie R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785058/ https://www.ncbi.nlm.nih.gov/pubmed/31596905 http://dx.doi.org/10.1371/journal.pone.0223725

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