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Motor cortex signals for each arm are mixed across hemispheres and neurons yet partitioned within the population response

Motor cortex (M1) has lateralized outputs, yet neurons can be active during movements of either arm. What is the nature and role of activity across the two hemispheres? We recorded muscles and neurons bilaterally while monkeys cycled with each arm. Most neurons were active during movement of either...

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Detalles Bibliográficos
Autores principales: Ames, Katherine Cora, Churchland, Mark M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785221/
https://www.ncbi.nlm.nih.gov/pubmed/31596230
http://dx.doi.org/10.7554/eLife.46159
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author Ames, Katherine Cora
Churchland, Mark M
author_facet Ames, Katherine Cora
Churchland, Mark M
author_sort Ames, Katherine Cora
collection PubMed
description Motor cortex (M1) has lateralized outputs, yet neurons can be active during movements of either arm. What is the nature and role of activity across the two hemispheres? We recorded muscles and neurons bilaterally while monkeys cycled with each arm. Most neurons were active during movement of either arm. Responses were strongly arm-dependent, raising two possibilities. First, population-level signals might differ depending on the arm used. Second, the same population-level signals might be present, but distributed differently across neurons. The data supported this second hypothesis. Muscle activity was accurately predicted by activity in either the ipsilateral or contralateral hemisphere. More generally, we failed to find signals unique to the contralateral hemisphere. Yet if signals are shared across hemispheres, how do they avoid impacting the wrong arm? We found that activity related to each arm occupies a distinct subspace, enabling muscle-activity decoders to naturally ignore signals related to the other arm.
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spelling pubmed-67852212019-10-10 Motor cortex signals for each arm are mixed across hemispheres and neurons yet partitioned within the population response Ames, Katherine Cora Churchland, Mark M eLife Neuroscience Motor cortex (M1) has lateralized outputs, yet neurons can be active during movements of either arm. What is the nature and role of activity across the two hemispheres? We recorded muscles and neurons bilaterally while monkeys cycled with each arm. Most neurons were active during movement of either arm. Responses were strongly arm-dependent, raising two possibilities. First, population-level signals might differ depending on the arm used. Second, the same population-level signals might be present, but distributed differently across neurons. The data supported this second hypothesis. Muscle activity was accurately predicted by activity in either the ipsilateral or contralateral hemisphere. More generally, we failed to find signals unique to the contralateral hemisphere. Yet if signals are shared across hemispheres, how do they avoid impacting the wrong arm? We found that activity related to each arm occupies a distinct subspace, enabling muscle-activity decoders to naturally ignore signals related to the other arm. eLife Sciences Publications, Ltd 2019-10-09 /pmc/articles/PMC6785221/ /pubmed/31596230 http://dx.doi.org/10.7554/eLife.46159 Text en © 2019, Ames and Churchland http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Ames, Katherine Cora
Churchland, Mark M
Motor cortex signals for each arm are mixed across hemispheres and neurons yet partitioned within the population response
title Motor cortex signals for each arm are mixed across hemispheres and neurons yet partitioned within the population response
title_full Motor cortex signals for each arm are mixed across hemispheres and neurons yet partitioned within the population response
title_fullStr Motor cortex signals for each arm are mixed across hemispheres and neurons yet partitioned within the population response
title_full_unstemmed Motor cortex signals for each arm are mixed across hemispheres and neurons yet partitioned within the population response
title_short Motor cortex signals for each arm are mixed across hemispheres and neurons yet partitioned within the population response
title_sort motor cortex signals for each arm are mixed across hemispheres and neurons yet partitioned within the population response
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785221/
https://www.ncbi.nlm.nih.gov/pubmed/31596230
http://dx.doi.org/10.7554/eLife.46159
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