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Motor cortex signals for each arm are mixed across hemispheres and neurons yet partitioned within the population response
Motor cortex (M1) has lateralized outputs, yet neurons can be active during movements of either arm. What is the nature and role of activity across the two hemispheres? We recorded muscles and neurons bilaterally while monkeys cycled with each arm. Most neurons were active during movement of either...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785221/ https://www.ncbi.nlm.nih.gov/pubmed/31596230 http://dx.doi.org/10.7554/eLife.46159 |
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author | Ames, Katherine Cora Churchland, Mark M |
author_facet | Ames, Katherine Cora Churchland, Mark M |
author_sort | Ames, Katherine Cora |
collection | PubMed |
description | Motor cortex (M1) has lateralized outputs, yet neurons can be active during movements of either arm. What is the nature and role of activity across the two hemispheres? We recorded muscles and neurons bilaterally while monkeys cycled with each arm. Most neurons were active during movement of either arm. Responses were strongly arm-dependent, raising two possibilities. First, population-level signals might differ depending on the arm used. Second, the same population-level signals might be present, but distributed differently across neurons. The data supported this second hypothesis. Muscle activity was accurately predicted by activity in either the ipsilateral or contralateral hemisphere. More generally, we failed to find signals unique to the contralateral hemisphere. Yet if signals are shared across hemispheres, how do they avoid impacting the wrong arm? We found that activity related to each arm occupies a distinct subspace, enabling muscle-activity decoders to naturally ignore signals related to the other arm. |
format | Online Article Text |
id | pubmed-6785221 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-67852212019-10-10 Motor cortex signals for each arm are mixed across hemispheres and neurons yet partitioned within the population response Ames, Katherine Cora Churchland, Mark M eLife Neuroscience Motor cortex (M1) has lateralized outputs, yet neurons can be active during movements of either arm. What is the nature and role of activity across the two hemispheres? We recorded muscles and neurons bilaterally while monkeys cycled with each arm. Most neurons were active during movement of either arm. Responses were strongly arm-dependent, raising two possibilities. First, population-level signals might differ depending on the arm used. Second, the same population-level signals might be present, but distributed differently across neurons. The data supported this second hypothesis. Muscle activity was accurately predicted by activity in either the ipsilateral or contralateral hemisphere. More generally, we failed to find signals unique to the contralateral hemisphere. Yet if signals are shared across hemispheres, how do they avoid impacting the wrong arm? We found that activity related to each arm occupies a distinct subspace, enabling muscle-activity decoders to naturally ignore signals related to the other arm. eLife Sciences Publications, Ltd 2019-10-09 /pmc/articles/PMC6785221/ /pubmed/31596230 http://dx.doi.org/10.7554/eLife.46159 Text en © 2019, Ames and Churchland http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Ames, Katherine Cora Churchland, Mark M Motor cortex signals for each arm are mixed across hemispheres and neurons yet partitioned within the population response |
title | Motor cortex signals for each arm are mixed across hemispheres and neurons yet partitioned within the population response |
title_full | Motor cortex signals for each arm are mixed across hemispheres and neurons yet partitioned within the population response |
title_fullStr | Motor cortex signals for each arm are mixed across hemispheres and neurons yet partitioned within the population response |
title_full_unstemmed | Motor cortex signals for each arm are mixed across hemispheres and neurons yet partitioned within the population response |
title_short | Motor cortex signals for each arm are mixed across hemispheres and neurons yet partitioned within the population response |
title_sort | motor cortex signals for each arm are mixed across hemispheres and neurons yet partitioned within the population response |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785221/ https://www.ncbi.nlm.nih.gov/pubmed/31596230 http://dx.doi.org/10.7554/eLife.46159 |
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