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Current Immune-Related Molecular Approach in Combating Nasopharyngeal Cancer
Nasopharyngeal cancer is a cancer closely related to Epstein-Barr virus (EBV) infection. EBV protein has been shown to be related to various oncogenic development. Suppression of tumor suppressor genes, upregulating molecules to prevent immune attack, downregulating pro-apoptotic proteins, and stimu...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elmer Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785271/ https://www.ncbi.nlm.nih.gov/pubmed/31636788 http://dx.doi.org/10.14740/wjon1214 |
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author | Gondhowiardjo, Soehartati A. Adham, Marlinda Kodrat, Henry Tobing, Demak Lumban Haryoga, I. Made Dwiyono, Agustinus Gatot Kristian, Yoseph Adi |
author_facet | Gondhowiardjo, Soehartati A. Adham, Marlinda Kodrat, Henry Tobing, Demak Lumban Haryoga, I. Made Dwiyono, Agustinus Gatot Kristian, Yoseph Adi |
author_sort | Gondhowiardjo, Soehartati A. |
collection | PubMed |
description | Nasopharyngeal cancer is a cancer closely related to Epstein-Barr virus (EBV) infection. EBV protein has been shown to be related to various oncogenic development. Suppression of tumor suppressor genes, upregulating molecules to prevent immune attack, downregulating pro-apoptotic proteins, and stimulating local immune suppressive environment are among some roles that EBV proteins can exert on host cells. All those factors combined together with underlying genetic susceptibility of host cells further increase the chance of nasopharyngeal cancer development. Approach targeting those carcinogenesis pathways has been tested with marginal benefit. A newer approach boosting immune cells to increase recognition of tumor antigen and promoting cytotoxic T cell attack has shown promising clinical benefit. Further combination of those immunotherapies with other modality, in particular radiotherapy, has resulted in amplification of cancer killing. |
format | Online Article Text |
id | pubmed-6785271 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Elmer Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-67852712019-10-21 Current Immune-Related Molecular Approach in Combating Nasopharyngeal Cancer Gondhowiardjo, Soehartati A. Adham, Marlinda Kodrat, Henry Tobing, Demak Lumban Haryoga, I. Made Dwiyono, Agustinus Gatot Kristian, Yoseph Adi World J Oncol Review Nasopharyngeal cancer is a cancer closely related to Epstein-Barr virus (EBV) infection. EBV protein has been shown to be related to various oncogenic development. Suppression of tumor suppressor genes, upregulating molecules to prevent immune attack, downregulating pro-apoptotic proteins, and stimulating local immune suppressive environment are among some roles that EBV proteins can exert on host cells. All those factors combined together with underlying genetic susceptibility of host cells further increase the chance of nasopharyngeal cancer development. Approach targeting those carcinogenesis pathways has been tested with marginal benefit. A newer approach boosting immune cells to increase recognition of tumor antigen and promoting cytotoxic T cell attack has shown promising clinical benefit. Further combination of those immunotherapies with other modality, in particular radiotherapy, has resulted in amplification of cancer killing. Elmer Press 2019-10 2019-09-20 /pmc/articles/PMC6785271/ /pubmed/31636788 http://dx.doi.org/10.14740/wjon1214 Text en Copyright 2019, Gondhowiardjo et al. http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Gondhowiardjo, Soehartati A. Adham, Marlinda Kodrat, Henry Tobing, Demak Lumban Haryoga, I. Made Dwiyono, Agustinus Gatot Kristian, Yoseph Adi Current Immune-Related Molecular Approach in Combating Nasopharyngeal Cancer |
title | Current Immune-Related Molecular Approach in Combating Nasopharyngeal Cancer |
title_full | Current Immune-Related Molecular Approach in Combating Nasopharyngeal Cancer |
title_fullStr | Current Immune-Related Molecular Approach in Combating Nasopharyngeal Cancer |
title_full_unstemmed | Current Immune-Related Molecular Approach in Combating Nasopharyngeal Cancer |
title_short | Current Immune-Related Molecular Approach in Combating Nasopharyngeal Cancer |
title_sort | current immune-related molecular approach in combating nasopharyngeal cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785271/ https://www.ncbi.nlm.nih.gov/pubmed/31636788 http://dx.doi.org/10.14740/wjon1214 |
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