A novel role for the late-onset Alzheimer’s disease (LOAD)-associated protein Bin1 in regulating postsynaptic trafficking and glutamatergic signaling

Postsynaptic trafficking plays a key role in regulating synapse structure and function. While spiny excitatory synapses can be stable throughout adult life, their morphology and function is impaired in Alzheimer’s disease (AD). However, little is known about how AD risk genes impact synaptic functio...

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Detalles Bibliográficos
Autores principales: Schürmann, Britta, Bermingham, Daniel P., Kopeikina, Katherine J., Myczek, Kristoffer, Yoon, Sehyoun, Horan, Katherine E., Kelly, Crystle J., Martin-de-Saavedra, Maria Dolores, Forrest, Marc P., Fawcett-Patel, Jessica M., Smith, Katharine R., Gao, Ruoqi, Bach, Anthony, Burette, Alain C., Rappoport, Joshua Z., Weinberg, Richard J., Martina, Marco, Penzes, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785379/
https://www.ncbi.nlm.nih.gov/pubmed/30967682
http://dx.doi.org/10.1038/s41380-019-0407-3

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