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Endoscopic Submucosal Dissection Followed by Concurrent Chemoradiotherapy in Patients with Early Esophageal Cancer with a High Risk of Lymph Node Metastasis

Endoscopic submucosal dissection is recommended as an alternative therapy for early esophageal cancer. However, achieving curative resection in this procedure remains controversial since precise prediction of lymph node metastasis can be difficult. Here, we present the preliminary results of endosco...

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Autores principales: Kim, Hee Kyung, Ko, Weon Jin, Kwon, Chang-Il, Song, Ga Won, Yoo, In Kyun, Song, Ji Hyun, Kim, Hak Su, Cho, Joo Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Gastrointestinal Endoscopy 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785410/
https://www.ncbi.nlm.nih.gov/pubmed/31085965
http://dx.doi.org/10.5946/ce.2018.176
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author Kim, Hee Kyung
Ko, Weon Jin
Kwon, Chang-Il
Song, Ga Won
Yoo, In Kyun
Song, Ji Hyun
Kim, Hak Su
Cho, Joo Young
author_facet Kim, Hee Kyung
Ko, Weon Jin
Kwon, Chang-Il
Song, Ga Won
Yoo, In Kyun
Song, Ji Hyun
Kim, Hak Su
Cho, Joo Young
author_sort Kim, Hee Kyung
collection PubMed
description Endoscopic submucosal dissection is recommended as an alternative therapy for early esophageal cancer. However, achieving curative resection in this procedure remains controversial since precise prediction of lymph node metastasis can be difficult. Here, we present the preliminary results of endoscopic submucosal dissection followed by concurrent chemoradiotherapy for early esophageal cancer with a high risk of lymph node metastasis. From May 2006 to January 2014, six patients underwent concurrent chemoradiotherapy after endoscopic submucosal dissection with a median follow-up period of 63 months. No complications were encountered during concurrent chemoradiotherapy. Although local recurrence did not occur in all patients, two patients were diagnosed with metachronous cancer. Overall, the survival rate was 100%. Thus, endoscopic submucosal dissection followed by concurrent chemoradiotherapy may be a feasible treatment for early esophageal cancer in patients with a high risk of lymph node metastasis. Future prospective large-scale studies are warranted to confirm our results.
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spelling pubmed-67854102019-10-17 Endoscopic Submucosal Dissection Followed by Concurrent Chemoradiotherapy in Patients with Early Esophageal Cancer with a High Risk of Lymph Node Metastasis Kim, Hee Kyung Ko, Weon Jin Kwon, Chang-Il Song, Ga Won Yoo, In Kyun Song, Ji Hyun Kim, Hak Su Cho, Joo Young Clin Endosc Case Report Endoscopic submucosal dissection is recommended as an alternative therapy for early esophageal cancer. However, achieving curative resection in this procedure remains controversial since precise prediction of lymph node metastasis can be difficult. Here, we present the preliminary results of endoscopic submucosal dissection followed by concurrent chemoradiotherapy for early esophageal cancer with a high risk of lymph node metastasis. From May 2006 to January 2014, six patients underwent concurrent chemoradiotherapy after endoscopic submucosal dissection with a median follow-up period of 63 months. No complications were encountered during concurrent chemoradiotherapy. Although local recurrence did not occur in all patients, two patients were diagnosed with metachronous cancer. Overall, the survival rate was 100%. Thus, endoscopic submucosal dissection followed by concurrent chemoradiotherapy may be a feasible treatment for early esophageal cancer in patients with a high risk of lymph node metastasis. Future prospective large-scale studies are warranted to confirm our results. Korean Society of Gastrointestinal Endoscopy 2019-09 2019-05-14 /pmc/articles/PMC6785410/ /pubmed/31085965 http://dx.doi.org/10.5946/ce.2018.176 Text en Copyright © 2019 Korean Society of Gastrointestinal Endoscopy This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Kim, Hee Kyung
Ko, Weon Jin
Kwon, Chang-Il
Song, Ga Won
Yoo, In Kyun
Song, Ji Hyun
Kim, Hak Su
Cho, Joo Young
Endoscopic Submucosal Dissection Followed by Concurrent Chemoradiotherapy in Patients with Early Esophageal Cancer with a High Risk of Lymph Node Metastasis
title Endoscopic Submucosal Dissection Followed by Concurrent Chemoradiotherapy in Patients with Early Esophageal Cancer with a High Risk of Lymph Node Metastasis
title_full Endoscopic Submucosal Dissection Followed by Concurrent Chemoradiotherapy in Patients with Early Esophageal Cancer with a High Risk of Lymph Node Metastasis
title_fullStr Endoscopic Submucosal Dissection Followed by Concurrent Chemoradiotherapy in Patients with Early Esophageal Cancer with a High Risk of Lymph Node Metastasis
title_full_unstemmed Endoscopic Submucosal Dissection Followed by Concurrent Chemoradiotherapy in Patients with Early Esophageal Cancer with a High Risk of Lymph Node Metastasis
title_short Endoscopic Submucosal Dissection Followed by Concurrent Chemoradiotherapy in Patients with Early Esophageal Cancer with a High Risk of Lymph Node Metastasis
title_sort endoscopic submucosal dissection followed by concurrent chemoradiotherapy in patients with early esophageal cancer with a high risk of lymph node metastasis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785410/
https://www.ncbi.nlm.nih.gov/pubmed/31085965
http://dx.doi.org/10.5946/ce.2018.176
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