Distinctive mutational spectrum and karyotype disruption in long-term cisplatin-treated urothelial carcinoma cell lines

The DNA-damaging compound cisplatin is broadly employed for cancer chemotherapy. The mutagenic effects of cisplatin on cancer cell genomes are poorly studied and might even contribute to drug resistance. We have therefore analyzed mutations and chromosomal alterations in four cisplatin-resistant bla...

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Detalles Bibliográficos
Autores principales: Skowron, Margaretha A., Petzsch, Patrick, Hardt, Karin, Wagner, Nicholas, Beier, Manfred, Stepanow, Stefanie, Drechsler, Matthias, Rieder, Harald, Köhrer, Karl, Niegisch, Günter, Hoffmann, Michèle J., Schulz, Wolfgang A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785536/
https://www.ncbi.nlm.nih.gov/pubmed/31597922
http://dx.doi.org/10.1038/s41598-019-50891-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785536/
https://www.ncbi.nlm.nih.gov/pubmed/31597922
http://dx.doi.org/10.1038/s41598-019-50891-w

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