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Bridging intestinal immunity and gut microbiota by metabolites

The gastrointestinal tract is the site of nutrient digestion and absorption and is also colonized by diverse, highly mutualistic microbes. The intestinal microbiota has diverse effects on the development and function of the gut-specific immune system, and provides some protection from infectious pat...

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Autores principales: Wang, Gang, Huang, Shuo, Wang, Yuming, Cai, Shuang, Yu, Haitao, Liu, Hongbing, Zeng, Xiangfang, Zhang, Guolong, Qiao, Shiyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785585/
https://www.ncbi.nlm.nih.gov/pubmed/31250035
http://dx.doi.org/10.1007/s00018-019-03190-6
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author Wang, Gang
Huang, Shuo
Wang, Yuming
Cai, Shuang
Yu, Haitao
Liu, Hongbing
Zeng, Xiangfang
Zhang, Guolong
Qiao, Shiyan
author_facet Wang, Gang
Huang, Shuo
Wang, Yuming
Cai, Shuang
Yu, Haitao
Liu, Hongbing
Zeng, Xiangfang
Zhang, Guolong
Qiao, Shiyan
author_sort Wang, Gang
collection PubMed
description The gastrointestinal tract is the site of nutrient digestion and absorption and is also colonized by diverse, highly mutualistic microbes. The intestinal microbiota has diverse effects on the development and function of the gut-specific immune system, and provides some protection from infectious pathogens. However, interactions between intestinal immunity and microorganisms are very complex, and recent studies have revealed that this intimate crosstalk may depend on the production and sensing abilities of multiple bioactive small molecule metabolites originating from direct produced by the gut microbiota or by the metabolism of dietary components. Here, we review the interplay between the host immune system and the microbiota, how commensal bacteria regulate the production of metabolites, and how these microbiota-derived products influence the function of several major innate and adaptive immune cells involved in modulating host immune homeostasis.
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spelling pubmed-67855852019-10-17 Bridging intestinal immunity and gut microbiota by metabolites Wang, Gang Huang, Shuo Wang, Yuming Cai, Shuang Yu, Haitao Liu, Hongbing Zeng, Xiangfang Zhang, Guolong Qiao, Shiyan Cell Mol Life Sci Review The gastrointestinal tract is the site of nutrient digestion and absorption and is also colonized by diverse, highly mutualistic microbes. The intestinal microbiota has diverse effects on the development and function of the gut-specific immune system, and provides some protection from infectious pathogens. However, interactions between intestinal immunity and microorganisms are very complex, and recent studies have revealed that this intimate crosstalk may depend on the production and sensing abilities of multiple bioactive small molecule metabolites originating from direct produced by the gut microbiota or by the metabolism of dietary components. Here, we review the interplay between the host immune system and the microbiota, how commensal bacteria regulate the production of metabolites, and how these microbiota-derived products influence the function of several major innate and adaptive immune cells involved in modulating host immune homeostasis. Springer International Publishing 2019-06-27 2019 /pmc/articles/PMC6785585/ /pubmed/31250035 http://dx.doi.org/10.1007/s00018-019-03190-6 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Wang, Gang
Huang, Shuo
Wang, Yuming
Cai, Shuang
Yu, Haitao
Liu, Hongbing
Zeng, Xiangfang
Zhang, Guolong
Qiao, Shiyan
Bridging intestinal immunity and gut microbiota by metabolites
title Bridging intestinal immunity and gut microbiota by metabolites
title_full Bridging intestinal immunity and gut microbiota by metabolites
title_fullStr Bridging intestinal immunity and gut microbiota by metabolites
title_full_unstemmed Bridging intestinal immunity and gut microbiota by metabolites
title_short Bridging intestinal immunity and gut microbiota by metabolites
title_sort bridging intestinal immunity and gut microbiota by metabolites
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785585/
https://www.ncbi.nlm.nih.gov/pubmed/31250035
http://dx.doi.org/10.1007/s00018-019-03190-6
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