Dual polymer networks: a new strategy in expanding the repertoire of hydrogels for biomedical applications

Inspired by the double network hydrogel systems we report the formulation of dual networks, which expands the repertoire of this class of materials for potential biomedical applications. The tough dual network hydrogels were designed through sequential interpenetrating polymer formation, applying green chemistry and low-cost methods, devoid of any initiator-activator complexes that may pose risks in biomedical applications. The dual networks were synthesized in two steps, firstly the water soluble poly(vinyl alcohol) was subjected to cryogelation that formed the first network, which was then expanded by intrusion of a dilute solution of sodium alginate and complexed with a solution of calcium chloride under ambient conditions and further freeze-thawed. These hydrogels are flexible, ductile and porous with the ability to absorb and retain fluids as well as possess the versatility to easily incorporate biological molecules/drugs/antibiotics to be applied in tissue matrices or drug delivery systems. The dual network hydrogels can be tailored to have varying mechanical properties, shapes, size, thickness and particularly can be made physically porous if required, to suit the users intended application.