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Supplemental study on 2’, 3’-Cyclic Nucleotide 3’-Phosphodiesterase (CNPase) activity in developing rat spinal cord lesions induced by hexachlorophene and cuprizone

In a previous study, we showed that 2’, 3’-Cyclic Nucleotide 3’-Phosphodiesterase (CNPase) expression is induced in different temporal patterns in the cerebrum, cerebellum and medulla oblongata of hexachlorophene (HCP) and cuprizone (CPZ) treated rats. Here, we additionally examined the histopatholo...

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Autores principales: KANNO, Takeshi, KUROTAKI, Tetsuro, YAMADA, Naoaki, TOMONARI, Yuki, SATO, Junko, TSUCHITANI, Minoru, KOBAYASHI, Yoshiyasu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785608/
https://www.ncbi.nlm.nih.gov/pubmed/31447458
http://dx.doi.org/10.1292/jvms.19-0096
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author KANNO, Takeshi
KUROTAKI, Tetsuro
YAMADA, Naoaki
TOMONARI, Yuki
SATO, Junko
TSUCHITANI, Minoru
KOBAYASHI, Yoshiyasu
author_facet KANNO, Takeshi
KUROTAKI, Tetsuro
YAMADA, Naoaki
TOMONARI, Yuki
SATO, Junko
TSUCHITANI, Minoru
KOBAYASHI, Yoshiyasu
author_sort KANNO, Takeshi
collection PubMed
description In a previous study, we showed that 2’, 3’-Cyclic Nucleotide 3’-Phosphodiesterase (CNPase) expression is induced in different temporal patterns in the cerebrum, cerebellum and medulla oblongata of hexachlorophene (HCP) and cuprizone (CPZ) treated rats. Here, we additionally examined the histopathological changes and CNPase expression in the spinal cord to clarify the reproducibility of different temporal patterns of CNPase expression in the spinal cord showing low degree or lack of spongy changes. Spongy changes were observed in HCP-treated rats, but not in CPZ-treated rats. Immunohistochemistry showed that intense expression of CNPase was not induced following HCP or CPZ treatment. Our data reveal that expression intensity of CNPase may be dependent on the degree of HCP- and CPZ-induced damage of the myelin sheath.
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spelling pubmed-67856082019-10-15 Supplemental study on 2’, 3’-Cyclic Nucleotide 3’-Phosphodiesterase (CNPase) activity in developing rat spinal cord lesions induced by hexachlorophene and cuprizone KANNO, Takeshi KUROTAKI, Tetsuro YAMADA, Naoaki TOMONARI, Yuki SATO, Junko TSUCHITANI, Minoru KOBAYASHI, Yoshiyasu J Vet Med Sci Pathology In a previous study, we showed that 2’, 3’-Cyclic Nucleotide 3’-Phosphodiesterase (CNPase) expression is induced in different temporal patterns in the cerebrum, cerebellum and medulla oblongata of hexachlorophene (HCP) and cuprizone (CPZ) treated rats. Here, we additionally examined the histopathological changes and CNPase expression in the spinal cord to clarify the reproducibility of different temporal patterns of CNPase expression in the spinal cord showing low degree or lack of spongy changes. Spongy changes were observed in HCP-treated rats, but not in CPZ-treated rats. Immunohistochemistry showed that intense expression of CNPase was not induced following HCP or CPZ treatment. Our data reveal that expression intensity of CNPase may be dependent on the degree of HCP- and CPZ-induced damage of the myelin sheath. The Japanese Society of Veterinary Science 2019-08-23 2019-09 /pmc/articles/PMC6785608/ /pubmed/31447458 http://dx.doi.org/10.1292/jvms.19-0096 Text en ©2019 The Japanese Society of Veterinary Science This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Pathology
KANNO, Takeshi
KUROTAKI, Tetsuro
YAMADA, Naoaki
TOMONARI, Yuki
SATO, Junko
TSUCHITANI, Minoru
KOBAYASHI, Yoshiyasu
Supplemental study on 2’, 3’-Cyclic Nucleotide 3’-Phosphodiesterase (CNPase) activity in developing rat spinal cord lesions induced by hexachlorophene and cuprizone
title Supplemental study on 2’, 3’-Cyclic Nucleotide 3’-Phosphodiesterase (CNPase) activity in developing rat spinal cord lesions induced by hexachlorophene and cuprizone
title_full Supplemental study on 2’, 3’-Cyclic Nucleotide 3’-Phosphodiesterase (CNPase) activity in developing rat spinal cord lesions induced by hexachlorophene and cuprizone
title_fullStr Supplemental study on 2’, 3’-Cyclic Nucleotide 3’-Phosphodiesterase (CNPase) activity in developing rat spinal cord lesions induced by hexachlorophene and cuprizone
title_full_unstemmed Supplemental study on 2’, 3’-Cyclic Nucleotide 3’-Phosphodiesterase (CNPase) activity in developing rat spinal cord lesions induced by hexachlorophene and cuprizone
title_short Supplemental study on 2’, 3’-Cyclic Nucleotide 3’-Phosphodiesterase (CNPase) activity in developing rat spinal cord lesions induced by hexachlorophene and cuprizone
title_sort supplemental study on 2’, 3’-cyclic nucleotide 3’-phosphodiesterase (cnpase) activity in developing rat spinal cord lesions induced by hexachlorophene and cuprizone
topic Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785608/
https://www.ncbi.nlm.nih.gov/pubmed/31447458
http://dx.doi.org/10.1292/jvms.19-0096
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