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VGLUT2 rs2290045 genotype moderates environmental sensitivity to alcohol-related problems in three samples of youths

The importance of Vesicular Glutamate Transporter 2 (VGLUT2)-mediated neurotransmission has been highlighted in studies on addiction-related phenotypes. The single nucleotide polymorphism rs2290045 in VGLUT2 has been associated with alcohol dependence, but it is unknown whether or how this associati...

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Autores principales: Vrettou, Maria, Nilsson, Kent W., Tuvblad, Catherine, Rehn, Mattias, Åslund, Cecilia, Andershed, Anna-Karin, Wallén-Mackenzie, Åsa, Andershed, Henrik, Hodgins, Sheilagh, Nylander, Ingrid, Comasco, Erika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785645/
https://www.ncbi.nlm.nih.gov/pubmed/30805764
http://dx.doi.org/10.1007/s00787-019-01293-w
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author Vrettou, Maria
Nilsson, Kent W.
Tuvblad, Catherine
Rehn, Mattias
Åslund, Cecilia
Andershed, Anna-Karin
Wallén-Mackenzie, Åsa
Andershed, Henrik
Hodgins, Sheilagh
Nylander, Ingrid
Comasco, Erika
author_facet Vrettou, Maria
Nilsson, Kent W.
Tuvblad, Catherine
Rehn, Mattias
Åslund, Cecilia
Andershed, Anna-Karin
Wallén-Mackenzie, Åsa
Andershed, Henrik
Hodgins, Sheilagh
Nylander, Ingrid
Comasco, Erika
author_sort Vrettou, Maria
collection PubMed
description The importance of Vesicular Glutamate Transporter 2 (VGLUT2)-mediated neurotransmission has been highlighted in studies on addiction-related phenotypes. The single nucleotide polymorphism rs2290045 in VGLUT2 has been associated with alcohol dependence, but it is unknown whether or how this association is affected by environmental factors. The present study determined whether the association of alcohol-related problems with the rs2290045 in the VGLUT2 gene was modified by negative and positive environmental factors. Three samples were included: a clinical sample of 131 adolescents followed from age 17 to 22; a general population sample of 1794 young adults; and a general population sample of 1687 adolescents followed from age 14 to 17. DNA was extracted from saliva and the rs2290045 (T/C) was genotyped. Alcohol-related problems were assessed using the Alcohol Use Disorders Identification Test. Stressful life events (SLE) and parenting were assessed by questionnaires. Gene-environment interactions were investigated using a dual statistical approach. In all samples (effect sizes 0.6–6.2%), and consistent with the differential susceptibility framework, T carriers exposed to SLE reported more alcohol-related problems if they had experienced poor parenting, and lower alcohol-related problems if they had received supportive parenting. T carriers not exposed to SLE reported higher alcohol-related problems if they had received supportive parenting and lower alcohol-related problems if they had received poor parenting. Among CC carriers, alcohol-related problems did not vary as a function of negative and positive environmental factors. In conclusion, in three samples of youths, alcohol-related problems were associated with an interaction of VGLUT2 rs2290045, SLE, and parenting. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00787-019-01293-w) contains supplementary material, which is available to authorized users.
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spelling pubmed-67856452019-10-17 VGLUT2 rs2290045 genotype moderates environmental sensitivity to alcohol-related problems in three samples of youths Vrettou, Maria Nilsson, Kent W. Tuvblad, Catherine Rehn, Mattias Åslund, Cecilia Andershed, Anna-Karin Wallén-Mackenzie, Åsa Andershed, Henrik Hodgins, Sheilagh Nylander, Ingrid Comasco, Erika Eur Child Adolesc Psychiatry Original Contribution The importance of Vesicular Glutamate Transporter 2 (VGLUT2)-mediated neurotransmission has been highlighted in studies on addiction-related phenotypes. The single nucleotide polymorphism rs2290045 in VGLUT2 has been associated with alcohol dependence, but it is unknown whether or how this association is affected by environmental factors. The present study determined whether the association of alcohol-related problems with the rs2290045 in the VGLUT2 gene was modified by negative and positive environmental factors. Three samples were included: a clinical sample of 131 adolescents followed from age 17 to 22; a general population sample of 1794 young adults; and a general population sample of 1687 adolescents followed from age 14 to 17. DNA was extracted from saliva and the rs2290045 (T/C) was genotyped. Alcohol-related problems were assessed using the Alcohol Use Disorders Identification Test. Stressful life events (SLE) and parenting were assessed by questionnaires. Gene-environment interactions were investigated using a dual statistical approach. In all samples (effect sizes 0.6–6.2%), and consistent with the differential susceptibility framework, T carriers exposed to SLE reported more alcohol-related problems if they had experienced poor parenting, and lower alcohol-related problems if they had received supportive parenting. T carriers not exposed to SLE reported higher alcohol-related problems if they had received supportive parenting and lower alcohol-related problems if they had received poor parenting. Among CC carriers, alcohol-related problems did not vary as a function of negative and positive environmental factors. In conclusion, in three samples of youths, alcohol-related problems were associated with an interaction of VGLUT2 rs2290045, SLE, and parenting. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00787-019-01293-w) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2019-02-25 2019 /pmc/articles/PMC6785645/ /pubmed/30805764 http://dx.doi.org/10.1007/s00787-019-01293-w Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Contribution
Vrettou, Maria
Nilsson, Kent W.
Tuvblad, Catherine
Rehn, Mattias
Åslund, Cecilia
Andershed, Anna-Karin
Wallén-Mackenzie, Åsa
Andershed, Henrik
Hodgins, Sheilagh
Nylander, Ingrid
Comasco, Erika
VGLUT2 rs2290045 genotype moderates environmental sensitivity to alcohol-related problems in three samples of youths
title VGLUT2 rs2290045 genotype moderates environmental sensitivity to alcohol-related problems in three samples of youths
title_full VGLUT2 rs2290045 genotype moderates environmental sensitivity to alcohol-related problems in three samples of youths
title_fullStr VGLUT2 rs2290045 genotype moderates environmental sensitivity to alcohol-related problems in three samples of youths
title_full_unstemmed VGLUT2 rs2290045 genotype moderates environmental sensitivity to alcohol-related problems in three samples of youths
title_short VGLUT2 rs2290045 genotype moderates environmental sensitivity to alcohol-related problems in three samples of youths
title_sort vglut2 rs2290045 genotype moderates environmental sensitivity to alcohol-related problems in three samples of youths
topic Original Contribution
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785645/
https://www.ncbi.nlm.nih.gov/pubmed/30805764
http://dx.doi.org/10.1007/s00787-019-01293-w
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