Rescue of Replication-Competent ZIKV Hidden in Placenta-Derived Mesenchymal Cells Long After the Resolution of the Infection

The Zika virus (ZIKV) genome, its negative-strand viral proteins, and virus-like particles were detected in placenta-derived mesenchymal cells (MSCs), indicating that ZIKV persists after virus clearance from maternal blood and can be rescued by in vitro cultivation. We report for the first time the...

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Detalles Bibliográficos
Autores principales: Bordoni, Veronica, Lalle, Eleonora, Colavita, Francesca, Baiocchini, Andrea, Nardacci, Roberta, Falasca, Laura, Carletti, Fabrizio, Cimini, Eleonora, Bordi, Licia, Kobinger, Gary, D’Ambrosio, Valentina, Natale, Fabio, Giancotti, Antonella, Manganaro, Lucia, Del Nonno, Franca, Zumla, Alimuddin, Liuzzi, Giuseppina, Ippolito, Giuseppe, Capobianchi, Maria Rosaria, Agrati, Chiara, Castilletti, Concetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785694/
https://www.ncbi.nlm.nih.gov/pubmed/31660333
http://dx.doi.org/10.1093/ofid/ofz342
Descripción
Sumario:The Zika virus (ZIKV) genome, its negative-strand viral proteins, and virus-like particles were detected in placenta-derived mesenchymal cells (MSCs), indicating that ZIKV persists after virus clearance from maternal blood and can be rescued by in vitro cultivation. We report for the first time the presence of replication-competent ZIKV in MSCs from an asymptomatic woman who acquired infection during pregnancy.

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