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Rescue of Replication-Competent ZIKV Hidden in Placenta-Derived Mesenchymal Cells Long After the Resolution of the Infection
The Zika virus (ZIKV) genome, its negative-strand viral proteins, and virus-like particles were detected in placenta-derived mesenchymal cells (MSCs), indicating that ZIKV persists after virus clearance from maternal blood and can be rescued by in vitro cultivation. We report for the first time the...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785694/ https://www.ncbi.nlm.nih.gov/pubmed/31660333 http://dx.doi.org/10.1093/ofid/ofz342 |
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| author | Bordoni, Veronica Lalle, Eleonora Colavita, Francesca Baiocchini, Andrea Nardacci, Roberta Falasca, Laura Carletti, Fabrizio Cimini, Eleonora Bordi, Licia Kobinger, Gary D’Ambrosio, Valentina Natale, Fabio Giancotti, Antonella Manganaro, Lucia Del Nonno, Franca Zumla, Alimuddin Liuzzi, Giuseppina Ippolito, Giuseppe Capobianchi, Maria Rosaria Agrati, Chiara Castilletti, Concetta |
| author_facet | Bordoni, Veronica Lalle, Eleonora Colavita, Francesca Baiocchini, Andrea Nardacci, Roberta Falasca, Laura Carletti, Fabrizio Cimini, Eleonora Bordi, Licia Kobinger, Gary D’Ambrosio, Valentina Natale, Fabio Giancotti, Antonella Manganaro, Lucia Del Nonno, Franca Zumla, Alimuddin Liuzzi, Giuseppina Ippolito, Giuseppe Capobianchi, Maria Rosaria Agrati, Chiara Castilletti, Concetta |
| author_sort | Bordoni, Veronica |
| collection | PubMed |
| description | The Zika virus (ZIKV) genome, its negative-strand viral proteins, and virus-like particles were detected in placenta-derived mesenchymal cells (MSCs), indicating that ZIKV persists after virus clearance from maternal blood and can be rescued by in vitro cultivation. We report for the first time the presence of replication-competent ZIKV in MSCs from an asymptomatic woman who acquired infection during pregnancy. |
| format | Online Article Text |
| id | pubmed-6785694 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | Oxford University Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-67856942019-10-15 Rescue of Replication-Competent ZIKV Hidden in Placenta-Derived Mesenchymal Cells Long After the Resolution of the Infection Bordoni, Veronica Lalle, Eleonora Colavita, Francesca Baiocchini, Andrea Nardacci, Roberta Falasca, Laura Carletti, Fabrizio Cimini, Eleonora Bordi, Licia Kobinger, Gary D’Ambrosio, Valentina Natale, Fabio Giancotti, Antonella Manganaro, Lucia Del Nonno, Franca Zumla, Alimuddin Liuzzi, Giuseppina Ippolito, Giuseppe Capobianchi, Maria Rosaria Agrati, Chiara Castilletti, Concetta Open Forum Infect Dis Brief Report The Zika virus (ZIKV) genome, its negative-strand viral proteins, and virus-like particles were detected in placenta-derived mesenchymal cells (MSCs), indicating that ZIKV persists after virus clearance from maternal blood and can be rescued by in vitro cultivation. We report for the first time the presence of replication-competent ZIKV in MSCs from an asymptomatic woman who acquired infection during pregnancy. Oxford University Press 2019-10-09 /pmc/articles/PMC6785694/ /pubmed/31660333 http://dx.doi.org/10.1093/ofid/ofz342 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
| spellingShingle | Brief Report Bordoni, Veronica Lalle, Eleonora Colavita, Francesca Baiocchini, Andrea Nardacci, Roberta Falasca, Laura Carletti, Fabrizio Cimini, Eleonora Bordi, Licia Kobinger, Gary D’Ambrosio, Valentina Natale, Fabio Giancotti, Antonella Manganaro, Lucia Del Nonno, Franca Zumla, Alimuddin Liuzzi, Giuseppina Ippolito, Giuseppe Capobianchi, Maria Rosaria Agrati, Chiara Castilletti, Concetta Rescue of Replication-Competent ZIKV Hidden in Placenta-Derived Mesenchymal Cells Long After the Resolution of the Infection |
| title | Rescue of Replication-Competent ZIKV Hidden in Placenta-Derived Mesenchymal Cells Long After the Resolution of the Infection |
| title_full | Rescue of Replication-Competent ZIKV Hidden in Placenta-Derived Mesenchymal Cells Long After the Resolution of the Infection |
| title_fullStr | Rescue of Replication-Competent ZIKV Hidden in Placenta-Derived Mesenchymal Cells Long After the Resolution of the Infection |
| title_full_unstemmed | Rescue of Replication-Competent ZIKV Hidden in Placenta-Derived Mesenchymal Cells Long After the Resolution of the Infection |
| title_short | Rescue of Replication-Competent ZIKV Hidden in Placenta-Derived Mesenchymal Cells Long After the Resolution of the Infection |
| title_sort | rescue of replication-competent zikv hidden in placenta-derived mesenchymal cells long after the resolution of the infection |
| topic | Brief Report |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785694/ https://www.ncbi.nlm.nih.gov/pubmed/31660333 http://dx.doi.org/10.1093/ofid/ofz342 |
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