Histological and toxicological evaluation, in rat, of a P-glycoprotein inducer and activator: 1-(propan-2-ylamino)-4-propoxy-9H-thioxanthen-9-one (TX5)

P-glycoprotein (P-gp) is an ATP-binding cassette transporter involved in the efflux of numerous compounds that influences the pharmacokinetics of xenobiotics. It reduces intestinal absorption and exposure of target cells to toxicity. Thioxanthones are compounds able to induce and/or activate P-gp in...

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Detalles Bibliográficos
Autores principales: Rocha-Pereira, Carolina, Silva, Vera, Costa, Vera Marisa, Silva, Renata, Garcia, Juliana, Gonçalves-Monteiro, Salomé, Duarte-Araújo, Margarida, Santos-Silva, Alice, Coimbra, Susana, Dinis-Oliveira, Ricardo Jorge, Lopes, Catarina, Silva, Paula, Long, Solida, Sousa, Emília, de Lourdes Bastos, Maria, Remião, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Leibniz Research Centre for Working Environment and Human Factors 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785774/
https://www.ncbi.nlm.nih.gov/pubmed/31611753
http://dx.doi.org/10.17179/excli2019-1675

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