Enhanced survival of human-induced pluripotent stem cell transplant in parkinsonian rat brain by locally applied cyclosporine

A major limitation with cell transplantation in patients is the unimpressive number of cells survived. The death of grafted cells involves apoptosis and immunorejection. In this review, we encapsulate the recent preclinical development that improves the survival of grafted cells and mitigates the im...

Descripción completa

Detalles Bibliográficos
Autores principales: Sheyner, Michael, Yu, Seong-Jin, Wang, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785947/
https://www.ncbi.nlm.nih.gov/pubmed/31620660
http://dx.doi.org/10.4103/bc.bc_40_19
_version_ 1783457993247948800
author Sheyner, Michael
Yu, Seong-Jin
Wang, Yun
author_facet Sheyner, Michael
Yu, Seong-Jin
Wang, Yun
author_sort Sheyner, Michael
collection PubMed
description A major limitation with cell transplantation in patients is the unimpressive number of cells survived. The death of grafted cells involves apoptosis and immunorejection. In this review, we encapsulate the recent preclinical development that improves the survival of grafted cells and mitigates the immunorejection of human-induced pluripotent stem cells (iPSCs) through co-grating nanoparticles-containing cyclosporine A (NanoCsA) in hemiparkinsonian rats. The study supported the notion that NanoCsA allows for long-lasting CsA discharge and limits immunorejection of human iPSC xenograft in a 6-hydroxydopamine Parkinson's disease rat model.
format Online
Article
Text
id pubmed-6785947
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Wolters Kluwer - Medknow
record_format MEDLINE/PubMed
spelling pubmed-67859472019-10-16 Enhanced survival of human-induced pluripotent stem cell transplant in parkinsonian rat brain by locally applied cyclosporine Sheyner, Michael Yu, Seong-Jin Wang, Yun Brain Circ Review Article A major limitation with cell transplantation in patients is the unimpressive number of cells survived. The death of grafted cells involves apoptosis and immunorejection. In this review, we encapsulate the recent preclinical development that improves the survival of grafted cells and mitigates the immunorejection of human-induced pluripotent stem cells (iPSCs) through co-grating nanoparticles-containing cyclosporine A (NanoCsA) in hemiparkinsonian rats. The study supported the notion that NanoCsA allows for long-lasting CsA discharge and limits immunorejection of human iPSC xenograft in a 6-hydroxydopamine Parkinson's disease rat model. Wolters Kluwer - Medknow 2019-09-30 /pmc/articles/PMC6785947/ /pubmed/31620660 http://dx.doi.org/10.4103/bc.bc_40_19 Text en Copyright: © 2019 Brain Circulation http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review Article
Sheyner, Michael
Yu, Seong-Jin
Wang, Yun
Enhanced survival of human-induced pluripotent stem cell transplant in parkinsonian rat brain by locally applied cyclosporine
title Enhanced survival of human-induced pluripotent stem cell transplant in parkinsonian rat brain by locally applied cyclosporine
title_full Enhanced survival of human-induced pluripotent stem cell transplant in parkinsonian rat brain by locally applied cyclosporine
title_fullStr Enhanced survival of human-induced pluripotent stem cell transplant in parkinsonian rat brain by locally applied cyclosporine
title_full_unstemmed Enhanced survival of human-induced pluripotent stem cell transplant in parkinsonian rat brain by locally applied cyclosporine
title_short Enhanced survival of human-induced pluripotent stem cell transplant in parkinsonian rat brain by locally applied cyclosporine
title_sort enhanced survival of human-induced pluripotent stem cell transplant in parkinsonian rat brain by locally applied cyclosporine
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785947/
https://www.ncbi.nlm.nih.gov/pubmed/31620660
http://dx.doi.org/10.4103/bc.bc_40_19
work_keys_str_mv AT sheynermichael enhancedsurvivalofhumaninducedpluripotentstemcelltransplantinparkinsonianratbrainbylocallyappliedcyclosporine
AT yuseongjin enhancedsurvivalofhumaninducedpluripotentstemcelltransplantinparkinsonianratbrainbylocallyappliedcyclosporine
AT wangyun enhancedsurvivalofhumaninducedpluripotentstemcelltransplantinparkinsonianratbrainbylocallyappliedcyclosporine

Ejemplares similares