Cargando…

Circular RNAs and neutrophils: Key factors in tackling asymptomatic moyamoya disease

Moyamoya disease (MMD) represents a rare steno-occlusive disorder affecting the terminal ends of the internal carotid artery and promoting the development of a poor, abnormal vascular network at the brain's base. Primarily affecting East Asian countries over Western populations, MMD can be furt...

Descripción completa

Detalles Bibliográficos
Autores principales: Corey, Sydney, Luo, Yumin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785948/
https://www.ncbi.nlm.nih.gov/pubmed/31620664
http://dx.doi.org/10.4103/bc.bc_38_19
_version_ 1783457993524772864
author Corey, Sydney
Luo, Yumin
author_facet Corey, Sydney
Luo, Yumin
author_sort Corey, Sydney
collection PubMed
description Moyamoya disease (MMD) represents a rare steno-occlusive disorder affecting the terminal ends of the internal carotid artery and promoting the development of a poor, abnormal vascular network at the brain's base. Primarily affecting East Asian countries over Western populations, MMD can be further divided into symptomatic and asymptomatic subtypes. The current knowledge of the underlying mechanisms and potential management strategies for asymptomatic cases of MMD are largely lacking and thus warrant investigation to elucidate the pathology of this rare disorder. Here, we assess research examining the expression profile of circular RNAs (circRNAs) of neutrophil transcriptome in asymptomatic MMD patients. These findings conclude that 123 differentially expressed circRNAs significantly contributed to metabolism, angiogenesis, and immune response. The hypoxia-inducing factor-1α signaling pathway was also revealed to be crucial in angiogenesis. We also evaluate current therapeutic options demonstrating the potential for MMD patients, such as EC-IC bypass and ischemic pre- and post-conditioning. These approaches combined with recent findings on the circRNA expression profile suggest a crucial role of anti-inflammatory and angiogenic-related mechanisms underlying MMD. Investigating the role of circRNAs and neutrophils in the asymptomatic MMD subtype may provide insight into its elusive pathology and direct future approaches to combat the progression of this rare disease.
format Online
Article
Text
id pubmed-6785948
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Wolters Kluwer - Medknow
record_format MEDLINE/PubMed
spelling pubmed-67859482019-10-16 Circular RNAs and neutrophils: Key factors in tackling asymptomatic moyamoya disease Corey, Sydney Luo, Yumin Brain Circ Review Article Moyamoya disease (MMD) represents a rare steno-occlusive disorder affecting the terminal ends of the internal carotid artery and promoting the development of a poor, abnormal vascular network at the brain's base. Primarily affecting East Asian countries over Western populations, MMD can be further divided into symptomatic and asymptomatic subtypes. The current knowledge of the underlying mechanisms and potential management strategies for asymptomatic cases of MMD are largely lacking and thus warrant investigation to elucidate the pathology of this rare disorder. Here, we assess research examining the expression profile of circular RNAs (circRNAs) of neutrophil transcriptome in asymptomatic MMD patients. These findings conclude that 123 differentially expressed circRNAs significantly contributed to metabolism, angiogenesis, and immune response. The hypoxia-inducing factor-1α signaling pathway was also revealed to be crucial in angiogenesis. We also evaluate current therapeutic options demonstrating the potential for MMD patients, such as EC-IC bypass and ischemic pre- and post-conditioning. These approaches combined with recent findings on the circRNA expression profile suggest a crucial role of anti-inflammatory and angiogenic-related mechanisms underlying MMD. Investigating the role of circRNAs and neutrophils in the asymptomatic MMD subtype may provide insight into its elusive pathology and direct future approaches to combat the progression of this rare disease. Wolters Kluwer - Medknow 2019-09-30 /pmc/articles/PMC6785948/ /pubmed/31620664 http://dx.doi.org/10.4103/bc.bc_38_19 Text en Copyright: © 2019 Brain Circulation http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review Article
Corey, Sydney
Luo, Yumin
Circular RNAs and neutrophils: Key factors in tackling asymptomatic moyamoya disease
title Circular RNAs and neutrophils: Key factors in tackling asymptomatic moyamoya disease
title_full Circular RNAs and neutrophils: Key factors in tackling asymptomatic moyamoya disease
title_fullStr Circular RNAs and neutrophils: Key factors in tackling asymptomatic moyamoya disease
title_full_unstemmed Circular RNAs and neutrophils: Key factors in tackling asymptomatic moyamoya disease
title_short Circular RNAs and neutrophils: Key factors in tackling asymptomatic moyamoya disease
title_sort circular rnas and neutrophils: key factors in tackling asymptomatic moyamoya disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785948/
https://www.ncbi.nlm.nih.gov/pubmed/31620664
http://dx.doi.org/10.4103/bc.bc_38_19
work_keys_str_mv AT coreysydney circularrnasandneutrophilskeyfactorsintacklingasymptomaticmoyamoyadisease
AT luoyumin circularrnasandneutrophilskeyfactorsintacklingasymptomaticmoyamoyadisease