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Construction of a novel MK-4 biosynthetic pathway in Pichia pastoris through heterologous expression of HsUBIAD1

BACKGROUND: With a variety of physiological and pharmacological functions, menaquinone is an essential prenylated product that can be endogenously converted from phylloquinone (VK(1)) or menadione (VK(3)) via the expression of Homo sapiens UBIAD1 (HsUBIAD1). The methylotrophic yeast, Pichia pastoris...

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Detalles Bibliográficos
Autores principales:	Sun, Xiaowen, Liu, Hui, Wang, Peng, wang, Li, Ni, Wenfeng, Yang, Qiang, Wang, Han, Tang, Hengfang, Zhao, Genhai, Zheng, Zhiming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6786277/ https://www.ncbi.nlm.nih.gov/pubmed/31601211 http://dx.doi.org/10.1186/s12934-019-1215-9

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