MeCP2-E1 isoform is a dynamically expressed, weakly DNA-bound protein with different protein and DNA interactions compared to MeCP2-E2

BACKGROUND: MeCP2—a chromatin-binding protein associated with Rett syndrome—has two main isoforms, MeCP2-E1 and MeCP2-E2, differing in a few N-terminal amino acid residues. Previous studies have shown brain region-specific expression of these isoforms which, in addition to their different cellular l...

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Detalles Bibliográficos
Autores principales: Martínez de Paz, Alexia, Khajavi, Leila, Martin, Hélène, Claveria-Gimeno, Rafael, Tom Dieck, Susanne, Cheema, Manjinder S., Sanchez-Mut, Jose V., Moksa, Malgorzata M., Carles, Annaick, Brodie, Nick I., Sheikh, Taimoor I., Freeman, Melissa E., Petrotchenko, Evgeniy V., Borchers, Christoph H., Schuman, Erin M., Zytnicki, Matthias, Velazquez-Campoy, Adrian, Abian, Olga, Hirst, Martin, Esteller, Manel, Vincent, John B., Malnou, Cécile E., Ausió, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6786283/
https://www.ncbi.nlm.nih.gov/pubmed/31601272
http://dx.doi.org/10.1186/s13072-019-0298-1

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