Overview of recent advances in liposomal nanoparticle-based cancer immunotherapy

The clinical performance of conventional cancer therapy approaches (surgery, radiotherapy, and chemotherapy) has been challenged by tumor metastasis and recurrence that is mainly responsible for cancer-caused mortalities. The cancer immunotherapy is being emerged nowadays as a promising therapeutic...

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Autores principales: Gao, Ang, Hu, Xian-li, Saeed, Madiha, Chen, Bin-fan, Li, Ya-ping, Yu, Hai-jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2019
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6786406/
https://www.ncbi.nlm.nih.gov/pubmed/31371782
http://dx.doi.org/10.1038/s41401-019-0281-1
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author Gao, Ang
Hu, Xian-li
Saeed, Madiha
Chen, Bin-fan
Li, Ya-ping
Yu, Hai-jun
author_facet Gao, Ang
Hu, Xian-li
Saeed, Madiha
Chen, Bin-fan
Li, Ya-ping
Yu, Hai-jun
author_sort Gao, Ang
collection PubMed
description The clinical performance of conventional cancer therapy approaches (surgery, radiotherapy, and chemotherapy) has been challenged by tumor metastasis and recurrence that is mainly responsible for cancer-caused mortalities. The cancer immunotherapy is being emerged nowadays as a promising therapeutic modality in order to achieve a highly efficient therapeutic performance while circumventing tumor metastasis and relapse. Liposomal nanoparticles (NPs) may serve as an ideal platform for systemic delivery of the immune modulators. In this review, we summarize the cutting-edge progresses in liposomal NPs for cancer immunotherapy, with focus on dendritic cells, T cells, tumor cells, natural killer cells, and macrophages. The review highlights the major challenges and provides a perspective regarding the clinical translation of liposomal nanoparticle-based immunotherapy.
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spelling pubmed-67864062020-08-28 Overview of recent advances in liposomal nanoparticle-based cancer immunotherapy Gao, Ang Hu, Xian-li Saeed, Madiha Chen, Bin-fan Li, Ya-ping Yu, Hai-jun Acta Pharmacol Sin Review Article The clinical performance of conventional cancer therapy approaches (surgery, radiotherapy, and chemotherapy) has been challenged by tumor metastasis and recurrence that is mainly responsible for cancer-caused mortalities. The cancer immunotherapy is being emerged nowadays as a promising therapeutic modality in order to achieve a highly efficient therapeutic performance while circumventing tumor metastasis and relapse. Liposomal nanoparticles (NPs) may serve as an ideal platform for systemic delivery of the immune modulators. In this review, we summarize the cutting-edge progresses in liposomal NPs for cancer immunotherapy, with focus on dendritic cells, T cells, tumor cells, natural killer cells, and macrophages. The review highlights the major challenges and provides a perspective regarding the clinical translation of liposomal nanoparticle-based immunotherapy. Springer Singapore 2019-08-01 2019-09 /pmc/articles/PMC6786406/ /pubmed/31371782 http://dx.doi.org/10.1038/s41401-019-0281-1 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Gao, Ang
Hu, Xian-li
Saeed, Madiha
Chen, Bin-fan
Li, Ya-ping
Yu, Hai-jun
Overview of recent advances in liposomal nanoparticle-based cancer immunotherapy
title Overview of recent advances in liposomal nanoparticle-based cancer immunotherapy
title_full Overview of recent advances in liposomal nanoparticle-based cancer immunotherapy
title_fullStr Overview of recent advances in liposomal nanoparticle-based cancer immunotherapy
title_full_unstemmed Overview of recent advances in liposomal nanoparticle-based cancer immunotherapy
title_short Overview of recent advances in liposomal nanoparticle-based cancer immunotherapy
title_sort overview of recent advances in liposomal nanoparticle-based cancer immunotherapy
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6786406/
https://www.ncbi.nlm.nih.gov/pubmed/31371782
http://dx.doi.org/10.1038/s41401-019-0281-1
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