Hypoxia induction in cultured pancreatic islets enhances endothelial cell morphology and survival while maintaining beta-cell function

BACKGROUND: Pancreatic islets are heavily vascularized in vivo yet lose this vasculature after only a few days in culture. Determining how to maintain islet vascularity in culture could lead to better outcomes in transplanting this tissue for the treatment of type 1 diabetes as well as provide insig...

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Detalles Bibliográficos
Autores principales: Sankar, Krishana S., Altamentova, Svetlana M., Rocheleau, Jonathan V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6786522/
https://www.ncbi.nlm.nih.gov/pubmed/31600313
http://dx.doi.org/10.1371/journal.pone.0222424

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6786522/
https://www.ncbi.nlm.nih.gov/pubmed/31600313
http://dx.doi.org/10.1371/journal.pone.0222424

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