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Inter-method and anatomical correlates of episodic memory tests in the Alzheimer’s Disease spectrum
BACKGROUND: Episodic memory impairments have been described as initial clinical findings in the Alzheimer’s Disease (AD) spectrum, which could be associated with the presence of early hippocampal dysfunction. However, correlates between performances in neuropsychological tests and hippocampal volume...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6786578/ https://www.ncbi.nlm.nih.gov/pubmed/31600312 http://dx.doi.org/10.1371/journal.pone.0223731 |
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author | Sudo, Felipe Kenji de Souza, Andrea Silveira Drummond, Claudia Assuncao, Naima Teldeschi, Alina Oliveira, Natalia Rodrigues, Fernanda Santiago-Bravo, Gustavo Calil, Victor Lima, Gabriel Erthal, Pilar Bernardes, Gabriel Monteiro, Marina Tovar-Moll, Fernanda Mattos, Paulo |
author_facet | Sudo, Felipe Kenji de Souza, Andrea Silveira Drummond, Claudia Assuncao, Naima Teldeschi, Alina Oliveira, Natalia Rodrigues, Fernanda Santiago-Bravo, Gustavo Calil, Victor Lima, Gabriel Erthal, Pilar Bernardes, Gabriel Monteiro, Marina Tovar-Moll, Fernanda Mattos, Paulo |
author_sort | Sudo, Felipe Kenji |
collection | PubMed |
description | BACKGROUND: Episodic memory impairments have been described as initial clinical findings in the Alzheimer’s Disease (AD) spectrum, which could be associated with the presence of early hippocampal dysfunction. However, correlates between performances in neuropsychological tests and hippocampal volumes in AD were inconclusive in the literature. Divergent methods to assess episodic memory have been depicted as a major source of heterogeneity across studies. METHODS: We examined correlates among performances in three different delayed-recall tasks (Rey-Auditory Verbal-Learning Test–RAVLT, Logical Memory and Visual Reproduction subtests from the Wechsler Memory Scale) and fully-automated volumetric measurements of the hippocampus (estimated using Neuroquant(®)) of 83 older subjects (47 controls, 27 Mild Cognitive Impairment individuals and 9 participants with Dementia due to AD). RESULTS: Inter-method correlations of episodic memory performances were at most moderate. Scores in the RAVLT predicted up to 48% of variance in HOC (Hippocampal Occupancy Score) among subjects in the AD spectrum. DISCUSSION: Tests using different stimuli (verbal or visual) and presenting distinct designs (word list, story or figure learning) may assess divergent aspects in episodic memory, with heterogeneous anatomical correlates. CONCLUSIONS: Different episodic memory tests might not assess the same construct and should not be used interchangeably. Scores in RAVLT may correlate with the presence of neurodegeneration in AD. |
format | Online Article Text |
id | pubmed-6786578 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-67865782019-10-19 Inter-method and anatomical correlates of episodic memory tests in the Alzheimer’s Disease spectrum Sudo, Felipe Kenji de Souza, Andrea Silveira Drummond, Claudia Assuncao, Naima Teldeschi, Alina Oliveira, Natalia Rodrigues, Fernanda Santiago-Bravo, Gustavo Calil, Victor Lima, Gabriel Erthal, Pilar Bernardes, Gabriel Monteiro, Marina Tovar-Moll, Fernanda Mattos, Paulo PLoS One Research Article BACKGROUND: Episodic memory impairments have been described as initial clinical findings in the Alzheimer’s Disease (AD) spectrum, which could be associated with the presence of early hippocampal dysfunction. However, correlates between performances in neuropsychological tests and hippocampal volumes in AD were inconclusive in the literature. Divergent methods to assess episodic memory have been depicted as a major source of heterogeneity across studies. METHODS: We examined correlates among performances in three different delayed-recall tasks (Rey-Auditory Verbal-Learning Test–RAVLT, Logical Memory and Visual Reproduction subtests from the Wechsler Memory Scale) and fully-automated volumetric measurements of the hippocampus (estimated using Neuroquant(®)) of 83 older subjects (47 controls, 27 Mild Cognitive Impairment individuals and 9 participants with Dementia due to AD). RESULTS: Inter-method correlations of episodic memory performances were at most moderate. Scores in the RAVLT predicted up to 48% of variance in HOC (Hippocampal Occupancy Score) among subjects in the AD spectrum. DISCUSSION: Tests using different stimuli (verbal or visual) and presenting distinct designs (word list, story or figure learning) may assess divergent aspects in episodic memory, with heterogeneous anatomical correlates. CONCLUSIONS: Different episodic memory tests might not assess the same construct and should not be used interchangeably. Scores in RAVLT may correlate with the presence of neurodegeneration in AD. Public Library of Science 2019-10-10 /pmc/articles/PMC6786578/ /pubmed/31600312 http://dx.doi.org/10.1371/journal.pone.0223731 Text en © 2019 Sudo et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Sudo, Felipe Kenji de Souza, Andrea Silveira Drummond, Claudia Assuncao, Naima Teldeschi, Alina Oliveira, Natalia Rodrigues, Fernanda Santiago-Bravo, Gustavo Calil, Victor Lima, Gabriel Erthal, Pilar Bernardes, Gabriel Monteiro, Marina Tovar-Moll, Fernanda Mattos, Paulo Inter-method and anatomical correlates of episodic memory tests in the Alzheimer’s Disease spectrum |
title | Inter-method and anatomical correlates of episodic memory tests in the Alzheimer’s Disease spectrum |
title_full | Inter-method and anatomical correlates of episodic memory tests in the Alzheimer’s Disease spectrum |
title_fullStr | Inter-method and anatomical correlates of episodic memory tests in the Alzheimer’s Disease spectrum |
title_full_unstemmed | Inter-method and anatomical correlates of episodic memory tests in the Alzheimer’s Disease spectrum |
title_short | Inter-method and anatomical correlates of episodic memory tests in the Alzheimer’s Disease spectrum |
title_sort | inter-method and anatomical correlates of episodic memory tests in the alzheimer’s disease spectrum |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6786578/ https://www.ncbi.nlm.nih.gov/pubmed/31600312 http://dx.doi.org/10.1371/journal.pone.0223731 |
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