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Characteristics and Clinical Outcomes of Critically Ill Cancer Patients Admitted to Korean Intensive Care Units
BACKGROUND: The objective of this study was to investigate the characteristics and clinical outcomes of critically ill cancer patients admitted to intensive care units (ICUs) in Korea. METHODS: This was a retrospective cohort study that analyzed prospective collected data from the Validation of Simp...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society of Critical Care Medicine
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6786698/ https://www.ncbi.nlm.nih.gov/pubmed/31723875 http://dx.doi.org/10.4266/acc.2018.00143 |
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author | Na, Soo Jin Ha, Tae Sun Koh, Younsuck Suh, Gee Young Koh, Shin Ok Lim, Chae-Man Choi, Won-Il Lee, Young-Joo Kim, Seok Chan Chon, Gyu Rak Kim, Je Hyeong Kim, Jae Yeol Lim, Jaemin Park, Sunghoon Kim, Ho Cheol Lee, Jin Hwa Lee, Ji Hyun Park, Jisook Cho, Juhee Jeon, Kyeongman |
author_facet | Na, Soo Jin Ha, Tae Sun Koh, Younsuck Suh, Gee Young Koh, Shin Ok Lim, Chae-Man Choi, Won-Il Lee, Young-Joo Kim, Seok Chan Chon, Gyu Rak Kim, Je Hyeong Kim, Jae Yeol Lim, Jaemin Park, Sunghoon Kim, Ho Cheol Lee, Jin Hwa Lee, Ji Hyun Park, Jisook Cho, Juhee Jeon, Kyeongman |
author_sort | Na, Soo Jin |
collection | PubMed |
description | BACKGROUND: The objective of this study was to investigate the characteristics and clinical outcomes of critically ill cancer patients admitted to intensive care units (ICUs) in Korea. METHODS: This was a retrospective cohort study that analyzed prospective collected data from the Validation of Simplified Acute Physiology Score 3 (SAPS3) in Korean ICU (VSKI) study, which is a nationwide, multicenter, and prospective study that considered 5,063 patients from 22 ICUs in Korea over a period of 7 months. Among them, patients older than 18 years of age who were diagnosed with solid or hematologic malignancies prior to admission to the ICU were included in the present study. RESULTS: During the study period, a total of 1,762 cancer patients were admitted to the ICUs and 833 of them were deemed eligible for analysis. Six hundred fifty-eight (79%) had solid tumors and 175 (21%) had hematologic malignancies, respectively. Respiratory problems (30.1%) was the most common reason leading to ICU admission. Patients with hematologic malignancies had higher Sequential Organ Failure Assessment (12 vs. 8, P<0.001) and SAPS3 (71 vs. 69, P<0.001) values and were more likely to be associated with chemotherapy, steroid therapy, and immunocompromised status versus patients with solid tumors. The use of inotropes/vasopressors, mechanical ventilation, and/or continuous renal replacement therapy was more frequently required in hematologic malignancy patients. Mortality rates in the ICU (41.7% vs. 24.6%, P<0.001) and hospital (53.1% vs. 38.6%, P=0.002) were higher in hematologic malignancy patients than in solid tumor patients. CONCLUSIONS: Cancer patients accounted for one-third of all patients admitted to the studied ICUs in Korea. Clinical characteristics were different according to the type of malignancy. Patients with hematologic malignancies had a worse prognosis than did patients with solid tumor. |
format | Online Article Text |
id | pubmed-6786698 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Korean Society of Critical Care Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-67866982019-11-13 Characteristics and Clinical Outcomes of Critically Ill Cancer Patients Admitted to Korean Intensive Care Units Na, Soo Jin Ha, Tae Sun Koh, Younsuck Suh, Gee Young Koh, Shin Ok Lim, Chae-Man Choi, Won-Il Lee, Young-Joo Kim, Seok Chan Chon, Gyu Rak Kim, Je Hyeong Kim, Jae Yeol Lim, Jaemin Park, Sunghoon Kim, Ho Cheol Lee, Jin Hwa Lee, Ji Hyun Park, Jisook Cho, Juhee Jeon, Kyeongman Acute Crit Care Original Article BACKGROUND: The objective of this study was to investigate the characteristics and clinical outcomes of critically ill cancer patients admitted to intensive care units (ICUs) in Korea. METHODS: This was a retrospective cohort study that analyzed prospective collected data from the Validation of Simplified Acute Physiology Score 3 (SAPS3) in Korean ICU (VSKI) study, which is a nationwide, multicenter, and prospective study that considered 5,063 patients from 22 ICUs in Korea over a period of 7 months. Among them, patients older than 18 years of age who were diagnosed with solid or hematologic malignancies prior to admission to the ICU were included in the present study. RESULTS: During the study period, a total of 1,762 cancer patients were admitted to the ICUs and 833 of them were deemed eligible for analysis. Six hundred fifty-eight (79%) had solid tumors and 175 (21%) had hematologic malignancies, respectively. Respiratory problems (30.1%) was the most common reason leading to ICU admission. Patients with hematologic malignancies had higher Sequential Organ Failure Assessment (12 vs. 8, P<0.001) and SAPS3 (71 vs. 69, P<0.001) values and were more likely to be associated with chemotherapy, steroid therapy, and immunocompromised status versus patients with solid tumors. The use of inotropes/vasopressors, mechanical ventilation, and/or continuous renal replacement therapy was more frequently required in hematologic malignancy patients. Mortality rates in the ICU (41.7% vs. 24.6%, P<0.001) and hospital (53.1% vs. 38.6%, P=0.002) were higher in hematologic malignancy patients than in solid tumor patients. CONCLUSIONS: Cancer patients accounted for one-third of all patients admitted to the studied ICUs in Korea. Clinical characteristics were different according to the type of malignancy. Patients with hematologic malignancies had a worse prognosis than did patients with solid tumor. Korean Society of Critical Care Medicine 2018-08 2018-08-31 /pmc/articles/PMC6786698/ /pubmed/31723875 http://dx.doi.org/10.4266/acc.2018.00143 Text en Copyright © 2018 The Korean Society of Critical Care Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Na, Soo Jin Ha, Tae Sun Koh, Younsuck Suh, Gee Young Koh, Shin Ok Lim, Chae-Man Choi, Won-Il Lee, Young-Joo Kim, Seok Chan Chon, Gyu Rak Kim, Je Hyeong Kim, Jae Yeol Lim, Jaemin Park, Sunghoon Kim, Ho Cheol Lee, Jin Hwa Lee, Ji Hyun Park, Jisook Cho, Juhee Jeon, Kyeongman Characteristics and Clinical Outcomes of Critically Ill Cancer Patients Admitted to Korean Intensive Care Units |
title | Characteristics and Clinical Outcomes of Critically Ill Cancer Patients Admitted to Korean Intensive Care Units |
title_full | Characteristics and Clinical Outcomes of Critically Ill Cancer Patients Admitted to Korean Intensive Care Units |
title_fullStr | Characteristics and Clinical Outcomes of Critically Ill Cancer Patients Admitted to Korean Intensive Care Units |
title_full_unstemmed | Characteristics and Clinical Outcomes of Critically Ill Cancer Patients Admitted to Korean Intensive Care Units |
title_short | Characteristics and Clinical Outcomes of Critically Ill Cancer Patients Admitted to Korean Intensive Care Units |
title_sort | characteristics and clinical outcomes of critically ill cancer patients admitted to korean intensive care units |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6786698/ https://www.ncbi.nlm.nih.gov/pubmed/31723875 http://dx.doi.org/10.4266/acc.2018.00143 |
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