Cargando…

Micro-RNA 150-5p predicts overt heart failure in patients with univentricular hearts

BACKGROUND: In patients with left heart failure, micro-RNAs (miRNAs) have been shown to be of diagnostic and prognostic value. The present study aims to identify those miRNAs in patients with univentricular heart (UVH) disease that may be associated with overt heart failure. METHODS: A large panel o...

Descripción completa

Detalles Bibliográficos
Autores principales: Abu-Halima, Masood, Meese, Eckart, Saleh, Mohamad Ali, Keller, Andreas, Abdul-Khaliq, Hashim, Raedle-Hurst, Tanja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6786722/
https://www.ncbi.nlm.nih.gov/pubmed/31600281
http://dx.doi.org/10.1371/journal.pone.0223606
_version_ 1783458127065120768
author Abu-Halima, Masood
Meese, Eckart
Saleh, Mohamad Ali
Keller, Andreas
Abdul-Khaliq, Hashim
Raedle-Hurst, Tanja
author_facet Abu-Halima, Masood
Meese, Eckart
Saleh, Mohamad Ali
Keller, Andreas
Abdul-Khaliq, Hashim
Raedle-Hurst, Tanja
author_sort Abu-Halima, Masood
collection PubMed
description BACKGROUND: In patients with left heart failure, micro-RNAs (miRNAs) have been shown to be of diagnostic and prognostic value. The present study aims to identify those miRNAs in patients with univentricular heart (UVH) disease that may be associated with overt heart failure. METHODS: A large panel of human miRNA arrays were used to determine miRNA expression profiles in the blood of 48 UVH patients and 32 healthy controls. For further selection, the most abundantly expressed miRNA arrays were related to clinical measures of heart failure and selected miRNAs validated by polymerase chain reaction were used for the prediction of overt heart failure and all-cause mortality. RESULTS: According to microarray analysis, 50 miRNAs were found to be significantly abundant in UVH patients of which miR-150-5p was best related to heart failure parameters. According to ROC analysis, NT-proBNP levels (AUC 0.940, 95% CI 0.873–1.000; p = 0.001), miR-150-5p (AUC 0.905, 95% CI 0.779–1.000; p = 0.001) and a higher NYHA class ≥ III (AUC 0.893, 95% CI 0.713–1.000; p = 0.002) were the 3 most significant predictors of overt heart failure. Using a combined biomarker model, AUC increased to 0.980 indicating an additive value of miR-150-5p. Moreover, in the multivariate analysis, a higher NYHA class ≥ III (p = 0.005) and miR-150-5p (p = 0.006) turned out to be independent predictors of overt heart failure. CONCLUSION: In patients with UVH, miR-150-5p is an independent predictor of overt heart failure and thus may be used in the risk assessment of these patients.
format Online
Article
Text
id pubmed-6786722
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-67867222019-10-19 Micro-RNA 150-5p predicts overt heart failure in patients with univentricular hearts Abu-Halima, Masood Meese, Eckart Saleh, Mohamad Ali Keller, Andreas Abdul-Khaliq, Hashim Raedle-Hurst, Tanja PLoS One Research Article BACKGROUND: In patients with left heart failure, micro-RNAs (miRNAs) have been shown to be of diagnostic and prognostic value. The present study aims to identify those miRNAs in patients with univentricular heart (UVH) disease that may be associated with overt heart failure. METHODS: A large panel of human miRNA arrays were used to determine miRNA expression profiles in the blood of 48 UVH patients and 32 healthy controls. For further selection, the most abundantly expressed miRNA arrays were related to clinical measures of heart failure and selected miRNAs validated by polymerase chain reaction were used for the prediction of overt heart failure and all-cause mortality. RESULTS: According to microarray analysis, 50 miRNAs were found to be significantly abundant in UVH patients of which miR-150-5p was best related to heart failure parameters. According to ROC analysis, NT-proBNP levels (AUC 0.940, 95% CI 0.873–1.000; p = 0.001), miR-150-5p (AUC 0.905, 95% CI 0.779–1.000; p = 0.001) and a higher NYHA class ≥ III (AUC 0.893, 95% CI 0.713–1.000; p = 0.002) were the 3 most significant predictors of overt heart failure. Using a combined biomarker model, AUC increased to 0.980 indicating an additive value of miR-150-5p. Moreover, in the multivariate analysis, a higher NYHA class ≥ III (p = 0.005) and miR-150-5p (p = 0.006) turned out to be independent predictors of overt heart failure. CONCLUSION: In patients with UVH, miR-150-5p is an independent predictor of overt heart failure and thus may be used in the risk assessment of these patients. Public Library of Science 2019-10-10 /pmc/articles/PMC6786722/ /pubmed/31600281 http://dx.doi.org/10.1371/journal.pone.0223606 Text en © 2019 Abu-Halima et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Abu-Halima, Masood
Meese, Eckart
Saleh, Mohamad Ali
Keller, Andreas
Abdul-Khaliq, Hashim
Raedle-Hurst, Tanja
Micro-RNA 150-5p predicts overt heart failure in patients with univentricular hearts
title Micro-RNA 150-5p predicts overt heart failure in patients with univentricular hearts
title_full Micro-RNA 150-5p predicts overt heart failure in patients with univentricular hearts
title_fullStr Micro-RNA 150-5p predicts overt heart failure in patients with univentricular hearts
title_full_unstemmed Micro-RNA 150-5p predicts overt heart failure in patients with univentricular hearts
title_short Micro-RNA 150-5p predicts overt heart failure in patients with univentricular hearts
title_sort micro-rna 150-5p predicts overt heart failure in patients with univentricular hearts
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6786722/
https://www.ncbi.nlm.nih.gov/pubmed/31600281
http://dx.doi.org/10.1371/journal.pone.0223606
work_keys_str_mv AT abuhalimamasood microrna1505ppredictsovertheartfailureinpatientswithuniventricularhearts
AT meeseeckart microrna1505ppredictsovertheartfailureinpatientswithuniventricularhearts
AT salehmohamadali microrna1505ppredictsovertheartfailureinpatientswithuniventricularhearts
AT kellerandreas microrna1505ppredictsovertheartfailureinpatientswithuniventricularhearts
AT abdulkhaliqhashim microrna1505ppredictsovertheartfailureinpatientswithuniventricularhearts
AT raedlehursttanja microrna1505ppredictsovertheartfailureinpatientswithuniventricularhearts